Sleep Deprivation and the Epigenome.
Sleep Deprivation and the Epigenome.
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DOI：
10.3389/fncir.2018.00014
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发表时间：
2018
影响因子：
3.5
通讯作者：
Abel T
中科院分区：
文献类型：
--
作者：
Gaine ME;Chatterjee S;Abel T
睡眠不足每天都会扰乱数百万人的生活，并对大脑的分子生物学产生深远的影响。这些影响始于神经元内DNA和RNA水平的变化，并导致神经元可塑性的改变和许多认知功能（包括学习和记忆）的失调。表观基因组在调节记忆储存过程中的基因表达方面起着至关重要的作用。在这篇综述文章中，我们首先描述了表观遗传改变对基因表达调控的影响，重点介绍了最常见的表观遗传机制：(i) DNA甲基化；组蛋白修饰；（iii）非编码rna。然后，我们讨论了证据表明，睡眠不足影响表观基因组，这些表观遗传的改变可能介导了睡眠中断后认知的变化。睡眠和表观基因组之间的联系才刚刚开始被阐明，但有明确的证据表明，睡眠剥夺后表观遗传会发生改变。在未来，这些表观基因组的变化可以作为睡眠缺失的生物标志物或作为睡眠相关疾病的治疗靶点。
Sleep deprivation disrupts the lives of millions of people every day and has a profound impact on the molecular biology of the brain. These effects begin as changes within a neuron, at the DNA and RNA level, and result in alterations in neuronal plasticity and dysregulation of many cognitive functions including learning and memory. The epigenome plays a critical role in regulating gene expression in the context of memory storage. In this review article, we begin by describing the effects of epigenetic alterations on the regulation of gene expression, focusing on the most common epigenetic mechanisms: (i) DNA methylation; (ii) histone modifications; and (iii) non-coding RNAs. We then discuss evidence suggesting that sleep loss impacts the epigenome and that these epigenetic alterations might mediate the changes in cognition seen following disruption of sleep. The link between sleep and the epigenome is only beginning to be elucidated, but clear evidence exists that epigenetic alterations occur following sleep deprivation. In the future, these changes to the epigenome could be utilized as biomarkers of sleep loss or as therapeutic targets for sleep-related disorders.
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影响因子：
4.8
作者：
Drake, Christopher L.;Jefferson, Catherine;Roth, Thomas
通讯作者：
Roth, Thomas
DOI：
10.1176/appi.ajp.2010.10040484
发表时间：
2010-12
期刊：
The American journal of psychiatry
影响因子：
--
作者：
Feyder M;Karlsson RM;Mathur P;Lyman M;Bock R;Momenan R;Munasinghe J;Scattoni ML;Ihne J;Camp M;Graybeal C;Strathdee D;Begg A;Alvarez VA;Kirsch P;Rietschel M;Cichon S;Walter H;Meyer-Lindenberg A;Grant SG;Holmes A
通讯作者：
Holmes A
影响因子：
4.4
作者：
Duan, Ruifeng;Liu, Xiaohua;Zhang, Zhiqing
通讯作者：
Zhang, Zhiqing
影响因子：
16.2
作者：
Cheng, Hai-Ying M.;Papp, Joseph W.;Obrietan, Karl
通讯作者：
Obrietan, Karl
影响因子：
5.6
作者：
Drake, C;Richardson, G;Roth, T
通讯作者：
Roth, T