Oral Minocycline Improved Keratosis Follicularis Squamosa (Dohi) and Related Disorder: Bacterial Factors are Possibly Involved in Abberant Keratinization
Oral Minocycline Improved Keratosis Follicularis Squamosa (Dohi) and Related Disorder: Bacterial Factors are Possibly Involved in Abberant Keratinization
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口服米诺环素可改善毛囊鳞状角化病 (Dohi) 及相关疾病：细菌因素可能与角化异常有关
DOI：
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发表时间：
1994
期刊：
影响因子：
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通讯作者：
K. Nishioka
中科院分区：
文献类型：
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作者：
I. Katayama;H. Yokozeki;K. Nishioka
我们用口服二甲胺四环素（50 ~ 100 mg/天）成功治疗了3例鳞状毛囊性角化病（Dohi）和1例网状乳头状瘤。临床效果首次出现在治疗开始后2周，未使用二甲胺四环素3个多月未见复发。4例患者毛囊及角质层均可见革兰氏阳性球菌。二甲胺四环素可能通过其在这些角化疾病中的杀菌作用来调节异常的角化。
Three cases of keratosis follicularis squamosa (Dohi) and one case of papillomatose confluente et reticulee were successfully treated with oral minocycline (50‐100 mg/day). The clinical effect first appeared at 2 weeks after the initiation of therapy and no recurrence was observed for more than 3 months without minocycline. Gram positive cocci were demonstrated inside the hair follicle and horny layers in all 4 case. Minocycline might modulate abberant keratinization through its bactericidal effects in these keratinizing disorders.
影响因子：
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作者：
B. Nickoloff
通讯作者：
B. Nickoloff