Paired-Box Gene 8 (PAX8) and Its Association With Epithelial Carcinomas.
Paired-Box Gene 8 (PAX8) and Its Association With Epithelial Carcinomas.
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DOI：
10.7759/cureus.17208
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发表时间：
2021-08
期刊：
影响因子：
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通讯作者：
Jean-Charles G
中科院分区：
文献类型：
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作者：
Khizer K;Padda J;Khedr A;Tasnim F;Al-Ewaidat OA;Patel V;Ismail D;Campos VYM;Jean-Charles G
癌症是美国第二大常见的死亡元凶，上皮癌被认为是最主要的癌症类型之一。上皮癌与配对盒基因 8 (PAX8) 之间的关联之前已得到大量研究。 PAX8属于配对盒基因家族，在不同身体器官系统的器官发生中发挥着重要作用，特别是甲状腺、肾脏系统和苗勒管系统。免疫组织化学染色用于检测不同上皮癌中 PAX8 的表达，并将其与 PAX8 阴性肿瘤区分开来。在滤泡性甲状腺癌、乳头状癌和未分化性甲状腺癌中，靶向 PAX8/过氧化物酶体增殖物激活受体 (PPAR) 融合蛋白被认为是一种潜在的治疗机制。此外，由于其在原发性卵巢癌中高表达，PAX8也被认为是卵巢癌治疗的靶点。需要更多的研究来测试使用 PAX8 作为治疗子宫内膜癌的可能靶点的可能性。在本文中，我们回顾了 PAX8 基因的功能、其突变如何导致某些上皮癌的发生、它如何用作诊断或预后标记物，以及它作为这些癌症的治疗靶点的潜力。
Cancer is the second most common culprit of mortality in the United States and epithelial carcinomas are considered as one of the most predominant types of cancer. The association between epithelial cancers and paired-box gene 8 (PAX8) has been studied significantly before. PAX8 belongs to the paired-box gene family, which plays an important role in the organogenesis of different body organ systems, especially the thyroid gland, the renal system, and the Müllerian system. Immunohistochemical staining is being used to detect PAX8 expression in different epithelial cancers and differentiate them from PAX8-negative tumors. In follicular, papillary, and anaplastic thyroid carcinomas, targeting the PAX8/peroxisome proliferator-activated receptors (PPARs) fusion protein is being considered as a potential mechanism for therapy. Moreover, because of its high expression in primary ovarian cancers, PAX8 is being considered as a target for ovarian cancer treatment as well. More studies are needed to test the possibility of using PAX8 as a possible target for managing endometrial carcinomas. In this article, we review the functions of the PAX8 gene, how its mutations lead to the development of certain epithelial carcinomas, how it can be used as a diagnostic or a prognostic marker, and its potential as a therapeutic target for these cancers.
影响因子：
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作者：
Milman, Tatyana;Mudhar, Hardeep Singh;Eagle Jr, Ralph C.
通讯作者：
Eagle Jr, Ralph C.