Resolving and characterizing the incidence of millihertz EEG modulation in critically ill children

Resolving and characterizing the incidence of millihertz EEG modulation in critically ill children
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解析和表征危重儿童毫赫兹脑电图调制的发生率

DOI:
10.1016/j.clinph.2022.02.010
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发表时间:
2022
影响因子:
4.7
通讯作者:
Ching, ShiNung
Ching, ShiNung
中科院分区:
医学3区
文献类型:
--
作者:
Loe, Maren E.;Khanmohammadi, Sina;Morrissey, Michael J.;Landre, Rebekah;Tomko, Stuart R.;Guerriero, Réjean M.;Ching, ShiNung

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目的分析连续监测的43例年轻危重症患者脑电图中的慢电模式——大周期振荡(MOs)。我们构建了新的定量方法来量化和理解MOs。方法采用非参数双水平谱分析鉴定MOs,在两个独立的ICU患者队列(n = 195)中,以毫赫(0.004-0.01 Hz)调制5-15 Hz的活动。我们还开发了一种严格的方法来量化MOs强度和空间表达,并通过替代噪声数据进行了验证。结果在高临床怀疑人群和普通ICU人群中均可出现强烈或广泛分布的多发性骨髓瘤。在前者中,具有强烈或空间广泛的MOs的患者往往具有较差的临床结果。一位患者的颅内压和心率数据为MOs的潜在更广泛的生理机制提供了见解。结论我们量化了危重儿科患者队列中的毫赫脑电图调制(MOs)。我们在两个患者群体中证实了高发病率。在高怀疑队列中,MOs与预后不良相关,提示未来作为诊断和预后辅助手段的潜力。这些结果支持了不同时间尺度的脑电图动力学的存在,并可能为幼儿脑损伤生理学提供见解。
ObjectiveWe analyze a slow electrographic pattern, Macroperiodic Oscillations (MOs), in the EEG from a cohort of young critical care patients (n = 43) with continuous EEG monitoring. We construct novel quantitative methods to quantify and understand MOs.MethodsWe applied a nonparametric bilevel spectral analysis to identify MOs, a millihertz (0.004–0.01 Hz) modulation of 5–15 Hz activity in two separate ICU patient cohorts (n = 195 total). We also developed a rigorous measure to quantify MOs strength and spatial expression, which was validated against surrogate noise data.ResultsStrong or spatially widespread MOs appear in both high clinical suspicion and a general ICU population. In the former, patients with strong or spatially widespread MOs tended to have worse clinical outcomes. Intracranial pressure and heart rate data from one patient provide insight into a potential broader physiological mechanism for MOs.ConclusionsWe quantified millihertz EEG modulation (MOs) in cohorts of critically ill pediatric patients. We demonstrated high incidence in two patient populations. In a high suspicion cohort, MOs are associated with poor outcome, suggesting future potential as a diagnostic and prognostic aid.SignificanceThese results support the existence of EEG dynamics across disparate time-scales and may provide insight into brain injury physiology in young children.
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