Resolving and characterizing the incidence of millihertz EEG modulation in critically ill children
Resolving and characterizing the incidence of millihertz EEG modulation in critically ill children
复制标题
解析和表征危重儿童毫赫兹脑电图调制的发生率
DOI:
10.1016/j.clinph.2022.02.010
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发表时间:
2022
影响因子:
4.7
通讯作者:
Ching, ShiNung
中科院分区:
文献类型:
--
作者:
Loe, Maren E.;Khanmohammadi, Sina;Morrissey, Michael J.;Landre, Rebekah;Tomko, Stuart R.;Guerriero, Réjean M.;Ching, ShiNung
ObjectiveWe analyze a slow electrographic pattern, Macroperiodic Oscillations (MOs), in the EEG from a cohort of young critical care patients (n = 43) with continuous EEG monitoring. We construct novel quantitative methods to quantify and understand MOs.MethodsWe applied a nonparametric bilevel spectral analysis to identify MOs, a millihertz (0.004–0.01 Hz) modulation of 5–15 Hz activity in two separate ICU patient cohorts (n = 195 total). We also developed a rigorous measure to quantify MOs strength and spatial expression, which was validated against surrogate noise data.ResultsStrong or spatially widespread MOs appear in both high clinical suspicion and a general ICU population. In the former, patients with strong or spatially widespread MOs tended to have worse clinical outcomes. Intracranial pressure and heart rate data from one patient provide insight into a potential broader physiological mechanism for MOs.ConclusionsWe quantified millihertz EEG modulation (MOs) in cohorts of critically ill pediatric patients. We demonstrated high incidence in two patient populations. In a high suspicion cohort, MOs are associated with poor outcome, suggesting future potential as a diagnostic and prognostic aid.SignificanceThese results support the existence of EEG dynamics across disparate time-scales and may provide insight into brain injury physiology in young children.
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影响因子:
14.5
作者:
Gong, Ruxue;Wegscheider, Mirko;Classen, Joseph
通讯作者:
Classen, Joseph
影响因子:
2.5
作者:
M. V. van Putten;M. Tjepkema;J. Hofmeijer
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J. Hofmeijer
影响因子:
3.6
作者:
E. Payne;Cecil D. Hahn
通讯作者:
Cecil D. Hahn
DOI:
--
发表时间:
2009
期刊:
Neurophysiologie clinique
影响因子:
--
作者:
A. Amantini;S. Fossi;A. Grippo;P. Innocenti;A. Amadori;L. Bucciardini;C. Cossu;C. Nardini;S. Scarpelli;V. Roma;Francesco Pinto
通讯作者:
Francesco Pinto
影响因子:
5.4
作者:
Adam S. Charles;A. Balavoine;C. Rozell
通讯作者:
C. Rozell