Chronic Antidepressant Treatment in Normal Mice Induces Anxiety and Impairs Stress-coping Ability.
Chronic Antidepressant Treatment in Normal Mice Induces Anxiety and Impairs Stress-coping Ability.
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正常小鼠中的慢性抗抑郁药治疗会诱发焦虑并损害压力解决能力。
DOI：
10.5607/en.2015.24.2.156
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发表时间：
2015-06
影响因子：
2.4
通讯作者：
Han PL
中科院分区：
文献类型：
--
作者：
Baek IS;Park JY;Han PL
抗抑郁药在临床上用于治疗重度抑郁症患者。抗抑郁治疗在某些患者群体中对缓解抑郁症和焦虑症有效。然而，目前尚不清楚健康人使用目前的抗抑郁药是否有利于即将到来的抑郁和焦虑诱导的生活事件。为了解决这个问题，正常小鼠腹腔注射丙咪嗪或氟西汀超过2周，并评估与焦虑和抑郁相关的行为。用丙咪嗪或氟西汀治疗超过14天的小鼠在强迫游泳试验和悬尾试验中表现出显著减少的不动时间，但这些小鼠在几个行为试验中表现出增强的焦虑。此外，在正常小鼠中，慢性抗抑郁药治疗后的亚阈值水平的应激严重加重了抗抑郁药诱导的焦虑样行为，而不会进一步影响抑郁相关行为。慢性抗抑郁药治疗后，亚阈值水平的压力产生肿胀的水泡和溃疡的嘴唇，以及水样和炎症的鼻子。给予慢性抗抑郁药治疗的小鼠表现出肠道异常，表现为小肠高度扩大和发炎，充满排便物质。这些结果表明，慢性抗抑郁治疗在正常小鼠中引起焦虑样行为，并损害他们的压力应对能力。
Antidepressants are clinically used for patients with major depression. Antidepressant treatments in certain groups of patients are effective for relieving depression as well as anxiety disorder. However, it is not clearly known whether the use of current antidepressants in healthy persons is beneficial for upcoming depression- and anxiety-inducing life events. To address this question, normal mice were intraperitoneally administered with imipramine or fluoxetine for more than 2 weeks, and behaviors related to anxiety and depression were evaluated. Mice treated with imipramine or fluoxetine for more than 14 days exhibited significantly decreased immobility time in the forced swim test and tail suspension test, but these mice exhibited enhanced anxiety in several behavioral tests. Furthermore, chronic antidepressant treatments followed by sub-threshold level of stress in normal mice profoundly aggravated antidepressant-induced anxiety-like behaviors without further affecting depression-related behaviors. Chronic antidepressant treatments followed by sub-threshold level of stress produced swollen vesicles and ulcerations on the lips as well as a watery and inflammatory nose. Mice given chronic antidepressant treatments displayed intestinal abnormalities evidenced by a highly enlarged and inflamed small intestine full of defecation materials. These results suggest that chronic antidepressant treatment in normal mice provokes anxiety-like behaviors and impairs their stress-coping ability.
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DOI：
10.1017/s1461145701002632
发表时间：
2001-12-01
影响因子：
4.8
作者：
Bagdy, G;Graf, M;Kantor, S
通讯作者：
Kantor, S
影响因子：
7.6
作者：
Baj, Gabriele;D'Alessandro, Valentina;Tongiorgi, Enrico
通讯作者：
Tongiorgi, Enrico
影响因子：
2.9
作者：
Griebel, G;Cohen, C;Sanger, DJ
通讯作者：
Sanger, DJ
DOI：
10.1016/j.molbrainres.2003.11.002
发表时间：
2004-02-05
期刊：
MOLECULAR BRAIN RESEARCH
影响因子：
--
作者：
Chourbaji, S;Hellweg, R;Gass, P
通讯作者：
Gass, P
重复服用氟西汀对 SHR 和 WKY 大鼠焦虑相关行为、中枢血清素能系统和促肾上腺皮质激素轴的影响
影响因子：
4.7
作者：
Durand, M;Berton, O;Chaouloff, F
通讯作者：
Chaouloff, F