Commentary: Loss of Function Dysbiosis Associated with Antibiotics and High Fat, High Sugar Diet
Commentary: Loss of Function Dysbiosis Associated with Antibiotics and High Fat, High Sugar Diet
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评论：与抗生素和高脂肪、高糖饮食相关的功能丧失、生态失调
DOI：
10.29245/2689-9981/2019/3.1141
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发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Aaron W. Miller
中科院分区：
文献类型：
--
作者：
Aaron W. Miller
在过去的十年中，对微生物组的研究蓬勃发展，部分原因是高通量分析技术（统称为“多组学”）的进步，这些技术允许调查高度复杂的生物系统，如宿主相关的微生物组1。在此期间，大量证据表明微生物组在维持健康方面发挥着重要作用2，3。微生物组在健康和疾病中的重要性部分源于这样一个事实，即居住在我们身体中的细菌数量大致等于我们自己的人体细胞数量，并且存在于我们体内和体外的微生物基因数量超过我们自己的基因20- 304，5倍。因此，虽然对微生物组的大部分关注历来集中在传染病上，但鉴于微生物组的普遍存在和健康益处的最新证据，传染病应被视为例外而不是规则。
Over the last decade, research into the microbiome has blossomed due in part to advances in high throughput analytical technologies (collectively considered “multi-omics”) that allow for the inquiry of highly complex biological systems such as the host-associated microbiome1. During this time, considerable evidence has emerged for the important role that the microbiome plays in maintaining health2,3. The importance of the microbiome in health and disease is derived in part from the fact that the number of bacteria that inhabits our bodies is roughly equal to the number of our own human cells and that the number of microbial genes present in and on our bodies outnumbers our own genes by a factor of 20– 304,5. Thus, while most of the attention on the microbiome has historically focused on infectious disease, given recent evidence of the ubiquity and health benefits of the microbiome, infectious disease should be considered the exception rather than the rule.
影响因子：
6.1
作者：
Popkin BM;Adair LS;Ng SW
通讯作者：
Ng SW