Angiotensin Converting Enzyme 2 (ACE2) in Pregnancy: Preeclampsia and Small for Gestational Age.
Angiotensin Converting Enzyme 2 (ACE2) in Pregnancy: Preeclampsia and Small for Gestational Age.
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DOI：
10.3389/fphys.2020.590787
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发表时间：
2020
影响因子：
4
通讯作者：
Pringle KG
中科院分区：
文献类型：
--
作者：
Tamanna S;Clifton VL;Rae K;van Helden DF;Lumbers ER;Pringle KG
血管紧张素(Ang)的失衡可能是子痫前期(PE)和胎儿生长不良的病理生理机制之一。我们测定了10例非妊娠妇女、59例正常妊娠妇女、25例小于胎龄儿(SGA，25例)、妊娠13-36周(13-36周)和14例妊娠晚期PE妇女的血浆血管紧张素转换酶和血管紧张素转换酶水平。正常妊娠组血浆ACE、ACE2、Ang-(1-7)水平及ACE2活性均显著高于非妊娠组，NEP水平无明显变化。SGA妊娠早、中期血清ACE、ACE2水平均高于正常妊娠妇女。PE患者血浆ACE、ACE2、NEP、Ang-(1-7)水平及ACE2活性均低于正常孕妇水平。妊娠期较高的血浆ACE2水平和活性可能是导致Ang-(1-7)水平升高的原因。妊娠早期血管紧张素转换酶和血管紧张素转换酶2水平的升高表明，这些酶可能被用作胎儿生长不良的潜在早期生物标志物。在患有PE的妇女中，足月ACE2和NEP水平的降低可能是导致Ang-(1-7)水平下降的原因之一。这些发现提示循环RAS中两个关键酶之间的功能失调关系参与了PE和SGA的发病机制。由于可溶性ACE2可以阻止新型冠状病毒SARS-CoV-2与膜结合ACE2的结合，因此ACE2与冠状病毒的相互作用及其对妊娠的影响有待进一步研究。
An imbalance in angiotensin (Ang) peptides could contribute to the pathophysiology of preeclampsia (PE) and poor fetal growth. We measured maternal plasma levels of Ang peptides and converting enzymes in non-pregnant women (n = 10), in normal pregnant women (n = 59), women delivering small for gestational age babies (SGA, n = 25) across gestation (13–36 weeks) and in women with PE (n = 14) in their third trimester. Plasma ACE, ACE2, and Ang-(1-7) levels, and ACE2 activity were significantly higher in normal pregnant women compared with non-pregnant women; neprilysin (NEP) levels were not changed. In SGA pregnancies, ACE and ACE2 levels were higher in early-mid pregnancy compared with normal pregnant women. In women with PE, plasma ACE, ACE2, NEP, and Ang-(1-7) levels and ACE2 activity were lower than levels in normal pregnant women. The higher plasma ACE2 levels and activity in pregnancy could be driving the higher Ang-(1-7) levels. The early gestation increases in ACE and ACE2 levels in SGA pregnancies highlights the possibility that these enzymes could be used as potential early biomarkers of poor fetal growth. In women with PE, the reduced ACE2 and NEP levels at term, could be contributing to the reduction in Ang-(1-7) levels. These findings suggest that dysfunctional relationships between two key enzymes in the circulating RAS are involved in the pathogenesis of PE and SGA. Since soluble ACE2 can prevent binding of the novel coronavirus, SARS-CoV-2, to membrane bound ACE2, the interplay between ACE2 and the coronavirus and its impact in pregnancy requires further investigation.
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影响因子：
3.8
作者：
Irani, R. A.;Xia, Y.
通讯作者：
Xia, Y.
DOI：
10.1111/ajo.12399
发表时间：
2015-10-01
影响因子：
1.7
作者：
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通讯作者：
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影响因子：
5.5
作者：
Gallagher, Patricia E.;Ferrario, Carlos M.;Tallant, E. Ann
通讯作者：
Tallant, E. Ann
影响因子：
4.5
作者：
Escobar, Elizabeth;Rodriguez-Reyna, Tatiana Sofia;Sotelo, Julio
通讯作者：
Sotelo, Julio
影响因子：
13.8
作者：
Turner AJ;Hiscox JA;Hooper NM
通讯作者：
Hooper NM