Spatio-temporal filtering properties of a dendritic cable with active spines: A modeling study in the spike-diffuse-spike framework
Spatio-temporal filtering properties of a dendritic cable with active spines: A modeling study in the spike-diffuse-spike framework
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具有活动棘的树突电缆的时空过滤特性：尖峰-扩散-尖峰框架中的建模研究
DOI：
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发表时间：
2006
影响因子：
1.2
通讯作者：
S. Coombes
中科院分区：
文献类型：
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作者：
Y. Timofeeva;G. Lord;S. Coombes
尖峰-弥散-尖峰(SDS)模型描述了具有主动树突刺的被动树。脊椎-头部动力学用一个简单的积分-点火过程来模拟，而脊椎之间的交流是由缆绳方程调节的。在这篇文章中，我们开发了一个计算框架，它允许研究嵌入在简单的一维电缆上的这种脊椎网络中的多个尖峰事件。在第一个例子中，这个系统被证明支持具有与在脊椎头部具有Hodgkin-Huxley动力学的模型中观察到的相同定性特征的跳跃波。此外，对于孤立的跳跃脉冲，它与解析计算的速度有很好的一致性。在用时变的外部输入驱动系统时，我们发现脊椎的分布在决定时空滤波特性方面起着至关重要的作用。特别是，响应周期性脉冲序列的SDS模型显示出脊柱密度和低通时间滤波之间的正相关关系，这与Rose和Fortune[1999]的实验结果一致，该文发表于《实验生物学杂志202：1281-1289》中的《在电感系统中生成时间过滤器的机制》。此外，我们还展示了观测到的波特性对电缆和脊椎头部产生的自然噪声源的稳健性，并强调了纯粹噪声诱导波和相干振荡的可能性。
The spike-diffuse-spike (SDS) model describes a passive dendritic tree with active dendritic spines. Spine-head dynamics is modeled with a simple integrate-and-fire process, whilst communication between spines is mediated by the cable equation. In this paper we develop a computational framework that allows the study of multiple spiking events in a network of such spines embedded on a simple one-dimensional cable. In the first instance this system is shown to support saltatory waves with the same qualitative features as those observed in a model with Hodgkin-Huxley kinetics in the spine-head. Moreover, there is excellent agreement with the analytically calculated speed for a solitary saltatory pulse. Upon driving the system with time-varying external input we find that the distribution of spines can play a crucial role in determining spatio-temporal filtering properties. In particular, the SDS model in response to periodic pulse train shows a positive correlation between spine density and low-pass temporal filtering that is consistent with the experimental results of Rose and Fortune [1999, ‘Mechanisms for generating temporal filters in the electrosensory system,’ The Journal of Experimental Biology 202: 1281–1289]. Further, we demonstrate the robustness of observed wave properties to natural sources of noise that arise both in the cable and the spine-head, and highlight the possibility of purely noise induced waves and coherent oscillations.
DOI：
10.1073/pnas.96.23.13438
发表时间：
1999-11-09
影响因子：
11.1
作者：
Dunaevsky, A;Tashiro, A;Yuste, R
通讯作者：
Yuste, R