Hydrostatic pressure as a driver of cell and tissue morphogenesis.

Hydrostatic pressure as a driver of cell and tissue morphogenesis.
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DOI:
10.1016/j.semcdb.2022.04.021
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发表时间:
2022-11
影响因子:
7.3
通讯作者:
Megason, Sean G.
Megason, Sean G.
中科院分区:
生物学2区
文献类型:
--
作者:
Chugh, Mayank;Munjal, Akankshi;Megason, Sean G.

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形态发生,即组织发育成功能性形状的过程,需要协调的机械力。目前大多数文献将来自肌动球蛋白网络的收缩力归因为组织形态发生的主要驱动力。来自不同物种的最新研究表明,来自流体的压力可以产生组织形态发生所需的变形。在这篇综述中,我们讨论了如何在细胞和组织水平上产生静水压力,以及压力如何引起变形。我们强调和审查的结果表明,从充满液体的管腔和细胞外基质的粘性凝胶样成分的压力的机械作用。我们还强调了细胞外压力和组织行为之间的相互作用和机械化学反馈,以驱动组织重塑。最后,我们对该领域的开放问题提供了观点,这将进一步加深我们的理解,以揭示发育过程中组织组织的新原则。
Morphogenesis, the process by which tissues develop into functional shapes, requires coordinated mechanical forces. Most current literature ascribes contractile forces derived from actomyosin networks as the major driver of tissue morphogenesis. Recent works from diverse species have shown that pressure derived from fluids can generate deformations necessary for tissue morphogenesis. In this review, we discuss how hydrostatic pressure is generated at the cellular and tissue level and how the pressure can cause deformations. We highlight and review findings demonstrating the mechanical roles of pressures from fluid-filled lumens and viscous gel-like components of the extracellular matrix. We also emphasise the interactions and mechanochemical feedbacks between extracellular pressures and tissue behaviour in driving tissue remodelling. Lastly, we offer perspectives on the open questions in the field that will further our understanding to uncover new principles of tissue organisation during development.
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