Quantitative magnetic resonance imaging towards clinical application in multiple sclerosis.
Quantitative magnetic resonance imaging towards clinical application in multiple sclerosis.
复制标题
定量磁共振成像在多发性硬化症中临床应用。
DOI：
10.1093/brain/awab029
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发表时间：
2021-06-22
期刊：
影响因子：
--
通讯作者：
MAGNIMS Study Group
中科院分区：
文献类型：
--
作者：
Granziera C;Wuerfel J;Barkhof F;Calabrese M;De Stefano N;Enzinger C;Evangelou N;Filippi M;Geurts JJG;Reich DS;Rocca MA;Ropele S;Rovira À;Sati P;Toosy AT;Vrenken H;Gandini Wheeler-Kingshott CAM;Kappos L;MAGNIMS Study Group
定量MRI提供了CNS微观结构完整性的生物物理测量，可以跨CNS区域、患者和中心进行比较。在多发性硬化症患者中，定量MRI技术，如弛豫测量、髓磷脂成像、磁化转移、扩散MRI、定量易感性制图和灌注MRI，可以通过深入了解疾病机制来补充传统MRI技术。这些包括：(i)病变外中枢神经系统组织（外观正常的组织）弥漫性损伤的存在和程度；（ii）局灶性病变损伤和修复的异质性；（iii）对中枢神经系统组织成分的特异性损伤。本文综述了定量MRI的最新技术进展，现有定量MRI技术的病理验证，以及定量MRI在多发性硬化症患者中的研究和临床应用。目前的临床成熟水平的每一个定量MRI技术，特别是关于其整合到临床常规，进行了讨论。我们的目标是更好地理解定量MRI如何通过改善多发性硬化症患者的分层、疾病进展评估和治疗反应评估来帮助临床实践。定量MRI技术提供了中枢神经系统显微结构完整性的生物物理测量。Granziera等人回顾了qMRI在多发性硬化症研究领域提供的信息，以及将qMRI技术转化为临床实践的潜力。
Quantitative MRI provides biophysical measures of the microstructural integrity of the CNS, which can be compared across CNS regions, patients, and centres. In patients with multiple sclerosis, quantitative MRI techniques such as relaxometry, myelin imaging, magnetization transfer, diffusion MRI, quantitative susceptibility mapping, and perfusion MRI, complement conventional MRI techniques by providing insight into disease mechanisms. These include: (i) presence and extent of diffuse damage in CNS tissue outside lesions (normal-appearing tissue); (ii) heterogeneity of damage and repair in focal lesions; and (iii) specific damage to CNS tissue components. This review summarizes recent technical advances in quantitative MRI, existing pathological validation of quantitative MRI techniques, and emerging applications of quantitative MRI to patients with multiple sclerosis in both research and clinical settings. The current level of clinical maturity of each quantitative MRI technique, especially regarding its integration into clinical routine, is discussed. We aim to provide a better understanding of how quantitative MRI may help clinical practice by improving stratification of patients with multiple sclerosis, and assessment of disease progression, and evaluation of treatment response. Quantitative MRI techniques provide biophysical measures of the microstructural integrity of the CNS. Granziera et al. review the information provided by qMRI in the field of multiple sclerosis research and the potential for translation of qMRI techniques into clinical practice.
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影响因子：
3.7
作者：
Bester M;Forkert ND;Stellmann JP;Stürner K;Aly L;Drabik A;Young KL;Heesen C;Fiehler J;Siemonsen S
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29
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