MicroRNAs in the Spinal Microglia Serve Critical Roles in Neuropathic Pain
MicroRNAs in the Spinal Microglia Serve Critical Roles in Neuropathic Pain
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脊髓小胶质细胞中的 MicroRNA 在神经病理性疼痛中发挥关键作用
DOI：
10.1007/s12035-020-02102-1
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发表时间：
2020-09
影响因子：
5.1
通讯作者：
Zhou Jun
中科院分区：
文献类型：
--
作者：
Tang Simin;Jing Huan;Song Fuhu;Huang Haicheng;Li Wenjun;Xie Guiling;Zhou Jun
Neuropathic pain (NP) can occur after peripheral nerve injury (PNI), and it can be converted into a maladaptive, detrimental phenotype that causes a long-term state of pain hypersensitivity. In the last decade, the discovery that dysfunctional microglia evoke pain, called "microgliopathic pain," has challenged traditional neuronal views of "pain" and has been extensively explored. Recent studies have shown that microRNAs (miRNAs) can act as activators or inhibitors of spinal microglia in NP conditions. We first briefly review spinal microglial activation in NP. We then comprehensively describe miRNA expression changes and their potential mechanisms in the response of microglia to nerve injury. We summarize the roles of the following two representative miRNAs: miR-124, which reverses NP by keeping microglia quiescent, and miR-155, which promotes NP following microglial activation. Finally, we focused on the therapeutic potential of microglial miRNAs in NP. The findings we summarized may be essential tools for basic research and clinical treatment of NP.
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影响因子：
2.9
作者：
Tian Xie;Jianrong Zhang;Zhenming Kang;Feng Liu;Zhan-zeng Lin
通讯作者：
Tian Xie;Jianrong Zhang;Zhenming Kang;Feng Liu;Zhan-zeng Lin
影响因子：
--
作者：
Wake H;Fields RD
通讯作者：
Fields RD
影响因子：
4
作者：
Yang Zhang;Hai-Lin Liu;Li-jun An;Lin Li;Meng Wei;D. Ge;Z. Su
通讯作者：
Yang Zhang;Hai-Lin Liu;Li-jun An;Lin Li;Meng Wei;D. Ge;Z. Su
DOI：
10.1016/j.bbi.2019.02.024
发表时间：
2019-08
期刊：
Brain, Behavior, and Immunity
影响因子：
--
作者：
B. Sabirzhanov;Yun Li;Marino Coll-Miro;Jessica J. Matyas;Junyun He;Alok Kumar;N. Ward;Jingwen Yu
通讯作者：
B. Sabirzhanov;Yun Li;Marino Coll-Miro;Jessica J. Matyas;Junyun He;Alok Kumar;N. Ward;Jingwen Yu
影响因子：
16.2
作者：
Park CK;Xu ZZ;Berta T;Han Q;Chen G;Liu XJ;Ji RR
通讯作者：
Ji RR