Irreversible change in the T1 temperature dependence with thermal dose using the proton resonance frequency-T1 technique.
Irreversible change in the T1 temperature dependence with thermal dose using the proton resonance frequency-T1 technique.
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DOI：
10.1002/mrm.24322
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发表时间：
2013-04
影响因子：
3.3
通讯作者：
Parker, Dennis L.
中科院分区：
文献类型：
--
作者：
Diakite, Mahamadou;Payne, Allison;Todd, Nick;Parker, Dennis L.
Denaturation of macromolecules within the tissues is believed to be the major factor contributing to the damage of tissues upon hyperthermia. As a result, the value of the spin-lattice relaxation time T1 of the tissue water, which is related to the translational and rotational rates of water, represents an intrinsic probe for investigating structural changes in tissues at high temperature. Therefore, the goal of the present work is to investigate whether the simultaneous measurement of temperature and T1 using a hybrid PRF-T1 measurement technique, can be used to detect irreversible changes in T1 that might be indicative of tissue damage. A new hybrid PRF-T1 sequence was implemented based on the variable flip angle DESPOT1 method from a standard 3D segmented EPI sequence by alternating two flip angles from measurement to measurement. The structural changes of the heated tissue volumes were analyzed based on the derived T1 values and the corresponding PRF temperatures. Using the hybrid PRF-T1 technique, we demonstrate that the change of spin lattice relaxation time T1 is reversible with temperature for low thermal dose (thermal dose ≤ 240 CEM43°C) and irreversible with temperature after significant accumulation of thermal dose in ex vivo chicken breast tissue. These results suggest that the hybrid PRF-T1 method may be a potentially powerful tool to investigate the extent and mechanism of heat damage of biological tissues.
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影响因子：
19.7
作者：
Hynynen, K;Vykhodtseva, NI;Jolesz, FA
通讯作者：
Jolesz, FA
影响因子：
3.3
作者：
KAMMAN, RL;GO, KG;BERENDSEN, HJC
通讯作者：
BERENDSEN, HJC
影响因子：
3.5
作者：
Morrell, Glen R.;Schabel, Matthias C.
通讯作者：
Schabel, Matthias C.
影响因子：
3.3
作者：
BERNSTEIN, MA;GRGIC, M;PELC, NJ
通讯作者：
PELC, NJ
影响因子：
3.3
作者：
Cunningham, Charles H.;Pauly, John M.;Nayak, Krishna S.
通讯作者：
Nayak, Krishna S.