Wheezing exacerbations in early childhood: evaluation, treatment, and recent advances relevant to the genesis of asthma.
Wheezing exacerbations in early childhood: evaluation, treatment, and recent advances relevant to the genesis of asthma.
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DOI：
10.1016/j.jaip.2014.06.024
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发表时间：
2014-09
影响因子：
9.4
通讯作者：
Heymann, Peter W.
中科院分区：
文献类型：
--
作者：
Miller, E. Kathryn;Avila, Pedro C.;Khan, Yasmin W.;Word, Carolyn R.;Pelz, Barry J.;Papadopoulos, Nikolaos G.;Peebles, R. Stokes, Jr.;Heymann, Peter W.
初级保健、医院和急诊科的卫生保健提供者以及过敏症专科医生和肺科医生经常看到幼儿期开始喘息的儿童。当一个年幼的孩子，如2岁的患者，被评估为喘息时，临床医生经常面临的一个挑战是确定这些症状是短暂的、病毒引起的喘息，还是存在足够的危险因素来怀疑孩子可能会复发性喘息并发展为哮喘。大多数影响预后的因素不是相互排斥的，而是相互关联的（即辅助因素），通常代表基因与环境的相互作用。许多这些风险因素已经并将继续在前瞻性研究中进行调查，以破译它们的相对重要性，并在未来开发新的治疗和干预措施。讨论了幼儿喘息的病因、诊断方法、治疗、预后因素和预防哮喘发展的潜在目标。
Children who begin wheezing during early childhood are frequently seen by health care providers in primary care, in hospitals, and in emergency departments, and by allergists and pulmonologists. When a young child, such as the 2 year-old patient presented here, is evaluated for wheezing, a frequent challenge for clinicians is to determine whether the symptoms represent transient, viral-induced wheezing or whether sufficient risk factors are present to suspect that the child may experience recurrent wheezing and develop asthma. Most factors that influence prognosis are not mutually exclusive, are interrelated (ie, cofactors), and often represent gene-environment interactions. Many of these risk factors have been, and continue to be, investigated in prospective studies to decipher their relative importance with the goal of developing new therapies and interventions in the future. The etiologies of wheezing in young children, diagnostic methods, treatment, prognostic factors, and potential targets for prevention of the development of asthma are discussed.
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DOI：
10.1164/rccm.200407-894oc
发表时间：
2005-02-15
影响因子：
24.7
作者：
Bisgaard, H;Zielen, S;Polos, P
通讯作者：
Polos, P
DOI：
10.1016/j.cct.2004.03.002
发表时间：
2004-06-01
期刊：
CONTROLLED CLINICAL TRIALS
影响因子：
--
作者：
Guilbert, TW;Morgan, WJ;Martinez, FD
通讯作者：
Martinez, FD
影响因子：
168.9
作者：
ARSHAD, SH;MATTHEWS, S;HIDE, DW
通讯作者：
HIDE, DW
影响因子：
158.5
作者：
Bisgaard, Hans;Hermansen, Mette Northman;Pipper, Christian Bressen
通讯作者：
Pipper, Christian Bressen
影响因子：
14.6
作者：
Azad, Meghan B.;Konya, Theodore;Kozyrskyj, Anita L.
通讯作者：
Kozyrskyj, Anita L.