Effects of methylphenidate on inhibitory control in hyperactive children
Effects of methylphenidate on inhibitory control in hyperactive children
复制标题
哌醋甲酯对多动儿童抑制控制的影响
DOI：
10.1007/bf00916508
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发表时间：
1989
影响因子：
3.6
通讯作者：
G. Logan
中科院分区：
文献类型：
--
作者：
R. Tannock;R. Schachar;Robert P. Carr;D. Chajczyk;G. Logan
本研究调查了哌醋甲酯 (MPH) 对多动儿童抑制控制的影响。采用双盲、安慰剂对照、受试者内（交叉）设计，其中 12 名 6 岁至 11 岁的儿童在每种药物条件下分别进行四次测试：0.3 mg/kg 和 1.0 mg/kg 哌醋甲酯以及安慰剂。相关测量包括（a）在停止任务上，在给定停止信号的情况下抑制对主要选择反应时间任务的响应的概率，以及（b）在匹配熟悉图形测试（MFFT）上的响应延迟和错误。 MPH 通过加速抑制过程来提高中枢抑制机制的效率，从而使孩子们能够更好地控制自己的行为，并使他们能够增加在收到停止信号时抑制反应的可能性。 MPH 增加了响应延迟，但没有减少 MFFT 的错误，并且对儿童任务表现的观察突出了与该任务相关的解释问题。 1.0 mg/kg 剂量下两项任务的表现均优于 0.3 mg/kg 剂量。
This study investigated the effects of methylphenidate (MPH) on inhibitory control in hyperactive children. A double-blind, placebo-control, withinsubject (crossover) design was used in which 12 children, between 6 and 11 years of age, were each tested four times in each drug condition: 0.3 mg/kg and 1.0 mg/kg of methylphenidate, and placebo. Dependent measures included (a) the probability of inhibiting responses to a primary choice reaction time task given a stop signal, on the Stopping Task, and (b) response latency and errors on the Matching Familiar Figures Test (MFFT). MPH improved the efficiency of the central inhibitory mechanism by speeding the inhibitory process, thereby affording the children greater control over their actions and enabling them to increase the probability with which they inhibited responses given a stop signal. MPH increased response latency but did not reduce errors on the MFFT, and observation of the children's task performance highlighted the interpretive problems associated with this task. Performance on both tasks was better at a dosage of 1.0 mg/kg than at 0.3 mg/kg.
哌醋甲酯对有儿童注意力缺陷障碍史的青少年的影响：I. 临床发现。
DOI：
10.1097/00004583-198705000-00015
发表时间：
1987
影响因子：
13.3
作者：
Klorman,R;Coons,HW;Borgstedt,AD
通讯作者：
Borgstedt,AD