Estrogen and estrogen receptors in the modulation of gastrointestinal epithelial secretion.
Estrogen and estrogen receptors in the modulation of gastrointestinal epithelial secretion.
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DOI：
10.18632/oncotarget.18313
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发表时间：
2017-11-14
期刊：
影响因子：
--
通讯作者：
Dong H
中科院分区：
文献类型：
--
作者：
Yang X;Guo Y;He J;Zhang F;Sun X;Yang S;Dong H
胃肠道上皮离子转运在人体的许多生理方面都具有重要意义，如维持全身体液平衡，并在常见胃肠道疾病的发生和进展中发挥重要作用。雌激素和雌激素受体已被证明可以调节胃肠道上皮离子分泌的活性。本文综述了雌激素和雌激素受体在调节胃肠道上皮分泌中的作用，并阐明了其潜在的机制。我们强调了雌激素和雌激素受体通过调节胃肠道上皮HCO3-和Cl-分泌在胃肠道上皮保护和体液平衡中的重要性，特别是基于我们在这一领域的研究关于十二指肠HCO3-分泌调节机制的最新信息。由于没有关于这一主题的综述，只有少数论文涉及主要问题，我们希望及时为雌激素与胃肠道疾病的关系提供新的视角。
Gastrointestinal (GI) epithelial ion transport is physiologically important in many aspects of humans, such as in maintaining fluid balance of whole body, and also plays a role in the development and progression of common GI disease. Estrogen and estrogen receptors have been shown to modulate the activity of epithelial ion secretion in GI tract. This review aims to address the current state of knowledge about the role of estrogen and estrogen receptors in modulation of GI epithelial secretion and to elucidate the underlying mechanisms. We highlight the recent findings regarding the importance of estrogen and estrogen receptors in GI epithelia protection and body fluid balance by modulation of gastrointestinal epithelial HCO3- and Cl- secretion, especially current information about the regulatory mechanisms of duodenal HCO3- secretion based on our study in this field. Since there are no reviews on this topic but only few papers to address the main issues, we hope to timely provide new perspectives for the association between estrogen and GI disease.
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