Acoustic propulsion of nanorod motors inside living cells.
Acoustic propulsion of nanorod motors inside living cells.
复制标题
活细胞内纳米棒电动机的声推进。
DOI:
10.1002/anie.201309629
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发表时间:
2014-03-17
影响因子:
16.6
通讯作者:
Mallouk, Thomas E.
中科院分区:
文献类型:
--
作者:
Wang, Wei;Li, Sixing;Mair, Lamar;Ahmed, Suzanne;Huang, Tony Jun;Mallouk, Thomas E.
We demonstrate the ultrasonic propulsion of rod-shaped nanomotors inside living HeLa cells. These nanomotors (gold rods ~ 300 nm in diameter and ~ 3 μm long) attach strongly to the external surface of the cells, and are readily internalized by incubation with the cells for periods longer than 24 h. Once inside the cells, the nanorod motors can be activated by resonant ultrasound operating at ~ 4 MHz, and show axial propulsion as well as spinning. The intracellular propulsion does not involve chemical fuels or high power ultrasound and the HeLa cells remain viable. Ultrasonic propulsion of nanomotors may thus provide a new tool for probing the response of living cells to internal mechanical excitation, for controllably manipulating intracellular organelles, and for biomedical applications.
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