Acoustic propulsion of nanorod motors inside living cells.

Acoustic propulsion of nanorod motors inside living cells.
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活细胞内纳米棒电动机的声推进。

DOI:
10.1002/anie.201309629
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发表时间:
2014-03-17
影响因子:
16.6
通讯作者:
Mallouk, Thomas E.
Mallouk, Thomas E.
中科院分区:
化学1区
文献类型:
--
作者:
Wang, Wei;Li, Sixing;Mair, Lamar;Ahmed, Suzanne;Huang, Tony Jun;Mallouk, Thomas E.

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我们在活的海拉细胞内展示了杆状纳米马达的超声波推进。这些纳米马达(直径约300纳米,长约3 μm的金棒)牢固地附着在细胞的外表面,并且很容易通过与细胞孵育超过24小时的时间而内化。一旦进入细胞,纳米棒马达可以在约4 MHz的谐振超声下被激活,并显示轴向推进和旋转。细胞内推进不需要化学燃料或高功率超声波,HeLa细胞仍然可以存活。因此,纳米马达的超声波推进可能为探测活细胞对内部机械激励的反应、控制胞内细胞器以及生物医学应用提供了一种新的工具。
We demonstrate the ultrasonic propulsion of rod-shaped nanomotors inside living HeLa cells. These nanomotors (gold rods ~ 300 nm in diameter and ~ 3 μm long) attach strongly to the external surface of the cells, and are readily internalized by incubation with the cells for periods longer than 24 h. Once inside the cells, the nanorod motors can be activated by resonant ultrasound operating at ~ 4 MHz, and show axial propulsion as well as spinning. The intracellular propulsion does not involve chemical fuels or high power ultrasound and the HeLa cells remain viable. Ultrasonic propulsion of nanomotors may thus provide a new tool for probing the response of living cells to internal mechanical excitation, for controllably manipulating intracellular organelles, and for biomedical applications.
DOI: 10.1021/nn204762w
发表时间: 2012-02-01
期刊: ACS NANO
影响因子: 17.1
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