Polymeric immunoglobulin receptor (PIGR) exerts oncogenic functions via activating ribosome pathway in hepatocellular carcinoma.
Polymeric immunoglobulin receptor (PIGR) exerts oncogenic functions via activating ribosome pathway in hepatocellular carcinoma.
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聚合免疫球蛋白受体（PIGR）通过激活肝细胞癌中的核糖体途径发挥致癌功能
DOI：
10.7150/ijms.49790
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发表时间：
2021
影响因子：
3.6
通讯作者：
Yang Z
中科院分区：
文献类型：
--
作者：
Zhang Y;Zhang J;Chen X;Yang Z
Objective: This report aimed to investigate the potential mechanism of polymeric immunoglobulin receptor (PIGR) in promoting cancer development in hepatocellular carcinoma (HCC). Methods: PIGR expression was investigated in Gene Expression Omnibus (GEO), Oncomine, The Cancer Genome Atlas (TCGA) and The Human Protein Atlas (HPA) databases. Relationships between PIGR and HCC survival and clinico-pathological features were conducted in TCGA. RNAseq of PIGR overexpression and knockdown samples in Bel-7404 cells were performed for identifying potential mechanisms. Results: PIGR was significantly overexpressed in tumors compared to nontumors and in HCC serum peripheral blood mononuclear cells (PBMC) than in healthy individuals (all p < 0.05). In TCGA, PIGR was highly altered in 14% HCC patients. PIGR upregulation was significantly associated with poor disease-free survival (p < 0.05). More patients recurred/progressed in PIGR altered group compared to unaltered group (p < 0.01). PIGR was significantly higher in HCC patients with incomplete cirrhosis (p < 0.001) and established cirrhosis (p < 0.05). Fewer patients had N0 lymph node stage in PIGR altered group than those in the unaltered group (p < 0.05). PIGR RNAseq revealed that ribosome signaling was the common pathway in PIGR overexpression and PIGR knockdown samples. RNAseq analysis indicated that RPL10, RPL10A, RPL12, RPL19, RPL36, RPL38, RPL41, RPL6, RPL8, RPS12, RPS14, RPS15A, RPS2, RPS27A and RPSA were significantly upregulated in PIGR overexpression group and downregulated in PIGR underexpression group (all p < 0.05). Conclusions: Aberrant PIGR was associated with HCC recurrence, and PIGR stimulated ribosome pathway might be a potential mechanism.
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影响因子：
7.3
作者：
Gao J;Aksoy BA;Dogrusoz U;Dresdner G;Gross B;Sumer SO;Sun Y;Jacobsen A;Sinha R;Larsson E;Cerami E;Sander C;Schultz N
通讯作者：
Schultz N
聚合免疫球蛋白受体在人肝细胞癌炎症诱导的肿瘤转移中的作用。
DOI：
10.1093/jnci/djr360
发表时间：
2011-11-16
期刊：
Journal of the National Cancer Institute
影响因子：
--
作者：
Ai J;Tang Q;Wu Y;Xu Y;Feng T;Zhou R;Chen Y;Gao X;Zhu Q;Yue X;Pan Q;Xu S;Li J;Huang M;Daugherty-Holtrop J;He Y;Xu HE;Fan J;Ding J;Geng M
通讯作者：
Geng M
影响因子：
14.9
作者：
Ritchie ME;Phipson B;Wu D;Hu Y;Law CW;Shi W;Smyth GK
通讯作者：
Smyth GK
乙型肝炎病毒相关肝细胞癌中肝组织与显微解剖肝细胞的病毒表达和分子谱分析。
影响因子：
7.4
作者：
Melis M;Diaz G;Kleiner DE;Zamboni F;Kabat J;Lai J;Mogavero G;Tice A;Engle RE;Becker S;Brown CR;Hanson JC;Rodriguez-Canales J;Emmert-Buck M;Govindarajan S;Kew M;Farci P
通讯作者：
Farci P
影响因子：
3.6
作者：
Arumugam, Prabhu;Bhattacharya, Satyajit;Kocher, Hemant M.
通讯作者：
Kocher, Hemant M.