CircRNA-1967 participates in the differentiation of goat SHF-SCs into hair follicle lineage by sponging miR-93-3p to enhance LEF1 expression
CircRNA-1967 participates in the differentiation of goat SHF-SCs into hair follicle lineage by sponging miR-93-3p to enhance LEF1 expression
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CircRNA-1967 通过海绵 miR-93-3p 增强 LEF1 表达参与山羊 SHF-SC 向毛囊谱系的分化
DOI：
10.1080/10495398.2021.1975729
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发表时间：
2021-09
期刊：
影响因子：
--
通讯作者：
Wenlin Bai
中科院分区：
文献类型：
--
作者：
Yubo Zhu;Yanru Wang;Junyin Zhao;Jincheng Shen;Zeying Wang;Man Bai;Yixing Fan;Ronghuan Yin;Yongjiang Mao;Wenlin Bai
Abstract Circular RNAs (circRNAs), a novel class of non-coding RNAs, can interact with miRNAs through a sequence-driven sponge mechanism, thereby regulating the expression of their downstream target genes. CircRNA-1967 was found in secondary hair follicles (SHFs) of cashmere goats, but its functions are not clear. Here, we showed that both circRNA-1967 and its host gene BNC2 had significantly higher expression in SHF bulge at anagen than those at telogen of cashmere goats. Also, circRNA-1967 participates in the differentiation of SHF stem cells (SHF-SCs) into hair follicle lineage in cashmere goats. RNA pull-down assay verified that circRNA-1967 interacts with miR-93-3p. We also indicated that circRNA-1967 promoted LEF1 expression in SHF-SCs of cashmere goats. By dual-luciferase reporter analysis, we found that circRNA-1967 up-regulated LEF1 expression through the miR-93-3p-mediated pathway. The results from this study demonstrated that circRNA-1967 participated in the differentiation of goat SHF-SCs into hair follicle lineage by sponging miR-93-3p to enhance LEF1 expression. Our founding might constitute a novel pathway for revealing the potential mechanism of the differentiation of SHF-SCs into hair follicle lineage in cashmere goats. Also, these results provided a valuable basis for further enhancing the intrinsic regeneration of cashmere goat SHFs with the formation and growth of cashmere fibers.
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DOI：
10.1016/s0093-3619(08)70911-0
发表时间：
2008
期刊：
Yearbook of Dermatology and Dermatologic Surgery
影响因子：
--
作者：
B. Thiers
通讯作者：
B. Thiers
绒山羊次级毛囊 lncRNA-HOTAIR 转录物的鉴定和分子分析揭示了整合的调控网络，其表达可能受其启动子甲基化调节
影响因子：
3.5
作者：
Jiao, Qian;Yin, Rong H.;Bai, Wen L.
通讯作者：
Bai, Wen L.
DOI：
10.1083/jcb.200102079
发表时间：
2001-08-06
期刊：
The Journal of cell biology
影响因子：
--
作者：
Wojcik SM;Longley MA;Roop DR
通讯作者：
Roop DR
影响因子：
2.9
作者：
Rothnagel, JA;Seki, T;Roop, DR
通讯作者：
Roop, DR
影响因子：
4.8
作者：
Wu Jiang-hong;Zhang Yan-jun;Zhang Wen-guang
通讯作者：
Zhang Wen-guang