Revisiting Traumatic Brain Injury: From Molecular Mechanisms to Therapeutic Interventions.
Revisiting Traumatic Brain Injury: From Molecular Mechanisms to Therapeutic Interventions.
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DOI：
10.3390/biomedicines8100389
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发表时间：
2020-09-29
期刊：
影响因子：
4.7
通讯作者：
Vaibhav K
中科院分区：
文献类型：
--
作者：
Jarrahi A;Braun M;Ahluwalia M;Gupta RV;Wilson M;Munie S;Ahluwalia P;Vender JR;Vale FL;Dhandapani KM;Vaibhav K
研究创伤性脑损伤的复杂分子机制对创伤性脑损伤的治疗具有重要意义。目前对脑外伤的治疗主要集中在稳定患者和缓解症状上。然而，该领域缺乏明确的治疗方法来防止细胞死亡、氧化应激和导致慢性病理的炎症级联反应。在治疗颅脑损伤中发生的机械损伤方面，几乎没有什么办法；然而，可以通过治疗干预来针对继发性损伤机制，如炎症、血脑屏障(BBB)破坏、水肿形成、兴奋毒性、氧化应激和细胞死亡。阐明继发性损伤的多种机制和研究神经保护性治疗药物的靶点对于开发新的治疗方法至关重要。因此，我们对脑创伤后从炎症到程序性细胞死亡的分子事件进行综述，并讨论当前的研究和最新的治疗策略，以帮助理解脑损伤介导的继发性损伤。
Studying the complex molecular mechanisms involved in traumatic brain injury (TBI) is crucial for developing new therapies for TBI. Current treatments for TBI are primarily focused on patient stabilization and symptom mitigation. However, the field lacks defined therapies to prevent cell death, oxidative stress, and inflammatory cascades which lead to chronic pathology. Little can be done to treat the mechanical damage that occurs during the primary insult of a TBI; however, secondary injury mechanisms, such as inflammation, blood-brain barrier (BBB) breakdown, edema formation, excitotoxicity, oxidative stress, and cell death, can be targeted by therapeutic interventions. Elucidating the many mechanisms underlying secondary injury and studying targets of neuroprotective therapeutic agents is critical for developing new treatments. Therefore, we present a review on the molecular events following TBI from inflammation to programmed cell death and discuss current research and the latest therapeutic strategies to help understand TBI-mediated secondary injury.
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影响因子：
5.1
作者：
Baker, Glen;Matveychuk, Dmitriy;Kar, Satyabrata
通讯作者：
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影响因子：
16.2
作者：
ANKARCRONA, M;DYPBUKT, JM;NICOTERA, P
通讯作者：
NICOTERA, P
影响因子：
2.9
作者：
Aoyama, N;Katayama, Y;Uwahodo, Y
通讯作者：
Uwahodo, Y
影响因子：
1.9
作者：
Afshari, Daryoush;Moradian, Nasrin;Rezaei, Mansour
通讯作者：
Rezaei, Mansour
影响因子：
7
作者：
Becher B;Segal BM
通讯作者：
Segal BM