Moderate-Intensity Exercise Affects Gut Microbiome Composition and Influences Cardiac Function in Myocardial Infarction Mice.
Moderate-Intensity Exercise Affects Gut Microbiome Composition and Influences Cardiac Function in Myocardial Infarction Mice.
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DOI：
10.3389/fmicb.2017.01687
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发表时间：
2017
影响因子：
5.2
通讯作者：
Xu D
中科院分区：
文献类型：
--
作者：
Liu Z;Liu HY;Zhou H;Zhan Q;Lai W;Zeng Q;Ren H;Xu D
体育锻炼通常被认为可以预防心血管疾病。最近的研究表明，运动可以改变肠道微生物群，而肠道微生物群的改变可以影响心脏功能。在这里，我们关注心肌梗死（MI）后运动、肠道微生物群和心功能之间的关系。4周龄C57BL/6J小鼠在跑步机上运动4周后行左冠状动脉结扎术。采用超声心动图评估心功能。在Illumina HiSeq平台上使用16S rRNA基因测序评估运动后和心肌梗死后的肠道微生物组。运动训练抑制心肌梗死后小鼠心输出量和卒中量的下降。此外，体育锻炼和心肌梗死导致肠道微生物组成的改变。运动训练增加了丁酸单胞菌和阿克曼氏菌的相对丰度。此外，还确定了与运动和心功能密切相关的24个主要谱系（主要来自Bacteroidetes、Barnesiella、Helicobacter、Parabacteroides、Porphyromonadaceae、Ruminococcaceae和Ureaplasma）。这些结果表明，运动训练除了改变肠道菌群外，还在一定程度上改善了心功能；因此，它们可以为使用运动训练治疗心血管疾病提供新的见解。
Physical exercise is commonly regarded as protective against cardiovascular disease (CVD). Recent studies have reported that exercise alters the gut microbiota and that modification of the gut microbiota can influence cardiac function. Here, we focused on the relationships among exercise, the gut microbiota and cardiac function after myocardial infarction (MI). Four-week-old C57BL/6J mice were exercised on a treadmill for 4 weeks before undergoing left coronary artery ligation. Cardiac function was assessed using echocardiography. Gut microbiomes were evaluated post-exercise and post-MI using 16S rRNA gene sequencing on an Illumina HiSeq platform. Exercise training inhibited declines in cardiac output and stroke volume in post-MI mice. In addition, physical exercise and MI led to alterations in gut microbial composition. Exercise training increased the relative abundance of Butyricimonas and Akkermansia. Additionally, key operational taxonomic units were identified, including 24 lineages (mainly from Bacteroidetes, Barnesiella, Helicobacter, Parabacteroides, Porphyromonadaceae, Ruminococcaceae, and Ureaplasma) that were closely related to exercise and cardiac function. These results suggested that exercise training improved cardiac function to some extent in addition to altering the gut microbiota; therefore, they could provide new insights into the use of exercise training for the treatment of CVD.
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DOI：
10.1161/circheartfailure.115.002314
发表时间：
2016-01
期刊：
Circulation. Heart failure
影响因子：
--
作者：
Organ CL;Otsuka H;Bhushan S;Wang Z;Bradley J;Trivedi R;Polhemus DJ;Tang WH;Wu Y;Hazen SL;Lefer DJ
通讯作者：
Lefer DJ
DOI：
10.1097/00075197-200503000-00016
发表时间：
2005-03-01
影响因子：
3.1
作者：
Alverdy, J;Zaborina, O;Wu, LC
通讯作者：
Wu, LC
DOI：
10.1099/00207713-51-6-2105
发表时间：
2001-11-01
影响因子：
2.8
作者：
Chamkha, M;Garcia, JL;Labat, M
通讯作者：
Labat, M
影响因子：
11
作者：
McCafferty, Jonathan;Muehlbauer, Marcus;Fodor, Anthony A.
通讯作者：
Fodor, Anthony A.
探索心力衰竭的微生物组。
影响因子：
--
作者：
Kitai T;Kirsop J;Tang WH
通讯作者：
Tang WH