Synergistic effect of sleep depth and seizures correlates with postictal heart rate.
Synergistic effect of sleep depth and seizures correlates with postictal heart rate.
复制标题
作者：
Schomer AC;Lynch M;Lowenhaupt S;Leonardo J;Baljak V;Clark M;Kapur J;Quigg M
我们的目的是确定记录癫痫发作后睡眠对心率的影响。我们前瞻性地采集了癫痫监护室住院患者的心率数据。我们分析了多次癫痫发作（n = 101）的患者（n = 42）与脑电图证实的事件的心率趋势。在每次发作前5分钟对患者的睡眠状态进行评分，并与发作后最低心率（PINHR）相关。癫痫发作前5分钟内的睡眠深度与PINHR相关（相关系数[CC] =-0.229，p <0.05）。当校正年龄、全身性强直阵挛发作和基线心率等协变量时，该结果更为显著和强化（CC =-0.272，95%置信区间=-0.392至-0.152，p <0.001）。睡眠深度是癫痫发作后心率变化的独立预测因素。睡眠中癫痫发作后心率下降可能是继发于非快速眼动睡眠对副交感神经张力的协同作用。
Our objective was to determine the effect of sleep on heart rate following a recorded seizure. We prospectively acquired heart rate data in hospitalized epilepsy monitoring unit patients. We analyzed heart rate trends for multiple seizures (n = 101) in patients (n = 42) with electroencephalographically confirmed events. The patienťs sleep state was scored for the 5 min preceding each seizure and correlated with the postictal nadir heart rate (PINHR). The depth of sleep during the 5 min before a seizure correlated (correlation coefficient [CC] = -.229, p < .05) with PINHR. This result was more significant and strengthened (CC = -.272, 95% confidence interval = -.392 to -.152, p < .001) when adjusted for covariates of age, generalized tonic–clonic seizures, and baseline heart rate. Sleep depth is an independent predictor of the change in heart rate following a seizure. Diminished heart rate following a seizure in the setting of sleep is likely secondary to non-rapid eye movement sleep’s synergistic effect on parasympathetic tone.
登录
查看更多内容
影响因子：
5.6
作者：
Lamberts, Robert J.;Thijs, Roland D.;Sander, Josemir W.
通讯作者：
Sander, Josemir W.
影响因子：
37.8
作者：
Fleg, JL;Morrell, CH;Lakatta, EG
通讯作者：
Lakatta, EG
影响因子：
3.3
作者：
FLEG, JL;OCONNOR, F;LAKATTA, EG
通讯作者：
LAKATTA, EG
影响因子：
9.9
作者：
OPPENHEIMER, SM;GELB, A;HACHINSKI, VC
通讯作者：
HACHINSKI, VC
影响因子：
2.5
作者：
Janssens, Wim;Willems, Rik;Buyse, Bertien
通讯作者：
Buyse, Bertien