Kinase-mediated signaling cascades in mood disorders and antidepressant treatment.
Kinase-mediated signaling cascades in mood disorders and antidepressant treatment.
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DOI：
10.1080/01677063.2016.1245303
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发表时间：
2016-09
影响因子：
1.9
通讯作者：
Duric V
中科院分区：
文献类型：
--
作者：
Yuan LL;Wauson E;Duric V
激酶介导的信号级联调节许多参与细胞内稳态的不同分子机制，并且被视为在情绪障碍（例如抑郁症）的病理生理学中强烈失调的最常见的细胞内过程之一。新出现的速效抗抑郁药能够实现治疗改善，可能部分是通过刺激激酶依赖性信号通路的活性。因此，我们对激酶如何促进抑郁症的发展和治疗的理解的进步似乎至关重要。然而，目前的研究仅限于单一或少数激酶，无法检测到新的激酶。在这里，我们回顾了快速发展的激酶组分析方法，允许同时识别多个激酶和激酶网络连接，分析技术限制和挑战，并讨论其未来的应用，情绪障碍和抗抑郁治疗。
Kinase-mediated signaling cascades regulate a number of different molecular mechanisms involved in cellular homeostasis, and are viewed as one of the most common intracellular processes that are robustly dysregulated in the pathophysiology of mood disorders such as depression. Newly emerged, rapid acting antidepressants are able to achieve therapeutic improvement, possibly in part, through stimulating activity of kinase-dependent signaling pathways. Thus, advancements in our understanding of how kinases may contribute to development and treatment of depression seem crucial. However, current investigations are limited to a single or small number of kinases and are unable to detect novel kinases. Here, we review fast developing kinome profiling approaches that allow identification of multiple kinases and kinase network connections simultaneously, analyze technical limitation and challenges, and discuss their future applications to mood disorders and antidepressant treatment.
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影响因子：
64.8
作者：
Autry, Anita E.;Adachi, Megunai;Nosyreva, Elena;Na, Elisa S.;Los, Maarten F.;Cheng, Peng-fei;Kavalali, Ege T.;Monteggia, Lisa M.
通讯作者：
Monteggia, Lisa M.
影响因子：
46.9
作者：
通讯作者：
--
影响因子：
4
作者：
Al-Ali, Hassan;Schuerer, Stephan C.;Bixby, John L.
通讯作者：
Bixby, John L.
影响因子：
11
作者：
Dwivedi, Y;Rizavi, HS;Pandey, GN
通讯作者：
Pandey, GN
影响因子：
10.6
作者：
Berman, RM;Cappiello, A;Krystal, JH
通讯作者：
Krystal, JH