Cardiovascular Involvement in Kawasaki Disease Is Much More Than Mere Coronary Arteritis.

Cardiovascular Involvement in Kawasaki Disease Is Much More Than Mere Coronary Arteritis.
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DOI:
10.3389/fped.2020.526969
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发表时间:
2020
影响因子:
2.6
通讯作者:
Singh S
Singh S
中科院分区:
医学3区
文献类型:
--
作者:
Pilania RK;Jindal AK;Bhattarai D;Naganur SH;Singh S

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川崎病(KD)是儿童获得性心脏病的常见病因。冠状动脉受累是KD患儿最严重的并发症。现在已经确定了这种情况下的几种非冠状动脉并发症,但这些往往被忽视。心肌炎是KD的一个组成部分,可能比冠状动脉异常更常见。在KD患者中也观察到心包受累和瓣膜异常。KD休克综合征现在越来越被认识到,可能很难在临床上与中毒性休克综合征相鉴别。内皮功能障碍在急性期和随访期均有报道。这可能是一个潜在的可改变的心血管风险因素。
Kawasaki disease (KD) is now a common cause of acquired heart disease in children. Coronary artery involvement is the most serious complication in children with KD. Several non-coronary complications have now been identified in this condition but these are often overlooked. Myocarditis is an integral component of KD and may be more common than coronary artery abnormalities. Pericardial involvement and valvular abnormalities have also been observed in patients with KD. KD shock syndrome is now being increasingly recognized and may be difficult to differentiate clinically from toxic shock syndrome. Endothelial dysfunction has been reported both during acute stage and also on follow-up. This may be a potentially modifiable cardiovascular risk factor.
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