Changes in functional lung regions during the course of radiation therapy and their potential impact on lung dosimetry for non-small cell lung cancer.
Changes in functional lung regions during the course of radiation therapy and their potential impact on lung dosimetry for non-small cell lung cancer.
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DOI：
10.1016/j.ijrobp.2014.01.044
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发表时间：
2014-05-01
影响因子：
7
通讯作者：
Kong, Feng-Ming (Spring)
中科院分区：
文献类型：
--
作者：
Meng, Xue;Frey, Kirk;Matuszak, Martha;Paul, Stanton;Ten Haken, Randall;Yu, Jinming;Kong, Feng-Ming (Spring)
To study changes in functional activity on ventilation (V)/perfusion (Q) single-photon emission computed tomography (SPECT) during radiation therapy (RT) and explore the impact of such changes on lung dosimetry in patients with non-small cell lung cancer (NSCLC). Fifteen NSCLC patients with centrally located tumors were enrolled. All patients were treated with definitive RT dose of ≥60 Gy. V/Q SPECTCT scans were performed prior to and after delivery of 45 Gy of fractionated RT. SPECT images were used to define temporarily dysfunctional regions of lung caused by tumor or other potentially reversible conditions as B3. The functional lung (FL) was defined on SPECT by 2 separate approaches: FL1, a threshold of 30% of the maximum uptake of the patient’s lung; and FL2, FL1 plus B3 region. The impact of changes in FL between initiation of RT and delivery of 45 Gy on lung dosimetry were analyzed. Fourteen patients (93%) had larger FL2 volumes than FL1 pre-RT (P<.001). Dysfunctional lung became functional in 11 patients (73%) on V SPECT and in 10 patients (67%) on Q SPECT. The dosimetric parameters generated from CT-based anatomical lung had significantly lower values in FL1 than FL2, with a median reduction in the volume of lung receiving a dose of at least 20 Gy (V20) of 3%, 5.6%, and mean lung dose of 0.95 and 1.55 on V and Q SPECT respectively. Regional ventilation and perfusion function improve significantly during RT in centrally located NSCLC. Lung dosimetry values vary notably between different definitions of functional lung.
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DOI：
10.1016/j.ijrobp.2005.02.010
发表时间：
2005-10-01
影响因子：
7
作者：
Kong, FM;Ten Haken, RK;Hayman, JA
通讯作者：
Hayman, JA
影响因子：
5.7
作者：
Lavrenkov, Konstantin;Christian, Judith A.;Brada, Michael
通讯作者：
Brada, Michael
影响因子：
5.7
作者：
Christian, JA;Partridge, M;Brada, M
通讯作者：
Brada, M
影响因子：
5.7
作者：
Seppenwoolde, Y;Engelsman, M;Lebesque, JV
通讯作者：
Lebesque, JV
DOI：
10.1016/j.ijrobp.2006.01.044
发表时间：
2006-07-15
影响因子：
7
作者：
Jeremic, Branislav;Milicic, Biljana;Milisavljevic, Slobodan
通讯作者：
Milisavljevic, Slobodan