Impact of Particle Size and Polydispersity Index on the Clinical Applications of Lipidic Nanocarrier Systems.
Impact of Particle Size and Polydispersity Index on the Clinical Applications of Lipidic Nanocarrier Systems.
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DOI：
10.3390/pharmaceutics10020057
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发表时间：
2018-05-18
期刊：
影响因子：
5.4
通讯作者：
Mozafari MR
中科院分区：
文献类型：
--
作者：
Danaei M;Dehghankhold M;Ataei S;Hasanzadeh Davarani F;Javanmard R;Dokhani A;Khorasani S;Mozafari MR
以脂质为基础的药物传递系统或脂质载体被广泛用于提高难溶性药物的生物利用度。它们具有结合亲脂和亲水分子的能力，并保护它们在体外和体内不被降解。脂基纳米载体的许多物理特性决定了它们的安全性、稳定性、有效性，以及它们在体外和体内的行为。这些包括平均粒径/直径和多分散性指数（PDI），这是它们相对于粒径分布的质量的指示。纳米载体制剂对特定给药途径的适用性取决于它们的平均直径、PDI和尺寸稳定性以及其他参数。控制和验证这些参数对纳米载体制剂的有效临床应用至关重要。本文综述了尺寸和PDI在成功设计、配方和开发用于制药、营养保健和其他应用的纳米系统中的重要意义。脂质体、纳米脂质体、囊状磷脂凝胶、固体脂质纳米粒、转移体和囊体是常用的脂类药物载体。一系列可用的分析技术用于表征脂质纳米载体配方的优点和局限性也被涵盖。
Lipid-based drug delivery systems, or lipidic carriers, are being extensively employed to enhance the bioavailability of poorly-soluble drugs. They have the ability to incorporate both lipophilic and hydrophilic molecules and protecting them against degradation in vitro and in vivo. There is a number of physical attributes of lipid-based nanocarriers that determine their safety, stability, efficacy, as well as their in vitro and in vivo behaviour. These include average particle size/diameter and the polydispersity index (PDI), which is an indication of their quality with respect to the size distribution. The suitability of nanocarrier formulations for a particular route of drug administration depends on their average diameter, PDI and size stability, among other parameters. Controlling and validating these parameters are of key importance for the effective clinical applications of nanocarrier formulations. This review highlights the significance of size and PDI in the successful design, formulation and development of nanosystems for pharmaceutical, nutraceutical and other applications. Liposomes, nanoliposomes, vesicular phospholipid gels, solid lipid nanoparticles, transfersomes and tocosomes are presented as frequently-used lipidic drug carriers. The advantages and limitations of a range of available analytical techniques used to characterize lipidic nanocarrier formulations are also covered.
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影响因子：
5.4
作者：
Bulbake U;Doppalapudi S;Kommineni N;Khan W
通讯作者：
Khan W
影响因子：
5.8
作者：
DUPLESSIS, J;RAMACHANDRAN, C;MULLER, DG
通讯作者：
MULLER, DG
影响因子：
5.8
作者：
Chen, Ming;Liu, Xiangli;Fahr, Alfred
通讯作者：
Fahr, Alfred
影响因子：
2.4
作者：
Benson, Heather A. E.
通讯作者：
Benson, Heather A. E.
DOI：
10.1073/pnas.1103573108
发表时间：
2011-04-19
影响因子：
11.1
作者：
Choi, Chung Hang J.;Zuckerman, Jonathan E.;Davis, Mark E.
通讯作者：
Davis, Mark E.