Low extracellular lysyl oxidase expression is associated with poor prognosis in patients with prostate cancer.
Low extracellular lysyl oxidase expression is associated with poor prognosis in patients with prostate cancer.
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细胞外赖氨酰氧化酶表达低与前列腺癌患者预后不良相关
DOI：
10.3892/ol.2016.5118
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发表时间：
2016-11
期刊：
影响因子：
2.9
通讯作者：
Song X
中科院分区：
文献类型：
--
作者：
Zheng W;Wang X;Chen Q;Fang K;Wang L;Chen F;Li X;Li Z;Wang J;Liu Y;Yang D;Song X
细胞外基质（ECM）的重塑，这是由赖氨酰氧化酶（LOX）诱导，已被证明伴随着肿瘤的进展，然而，LOX表达水平和前列腺癌（Pca）的恶性行为之间的关联仍然不清楚。本研究旨在分析LOX在Pca患者中的肿瘤相关表达谱，并评估其潜在的预后价值。采用回顾性研究的方法，通过免疫组织化学方法分析前列腺增生症和前列腺癌组织中LOX和I型胶原的表达模式。结果表明，随着Pca的发生和发展，LOX和I型胶原的表达水平与Gleason评分和肿瘤分期密切相关。此外，尽管LOX在癌组织和非癌组织中表达，但在Pca细胞的ECM中观察到的差异表达模式可能表明LOX是影响该疾病进展的重要分子。因此，ECM中LOX表达水平可作为Pca的独立预测因子。
Remodeling of the extracellular matrix (ECM), which is induced by lysyl oxidase (LOX), has been demonstrated to accompany tumor progression; however, the association between LOX expression levels and the malignant behavior of prostate cancer (Pca) remains unclear. The present study aimed to analyze the tumor-associated expression profile of LOX in patients with Pca and to evaluate its potential prognostic value. In the form of a retrospective study, the expression patterns of LOX and collagen I were analyzed in patients with benign prostate hyperplasia and Pca by immunohistochemical examination. The results demonstrated that, with the initiation and progression of Pca, the expression levels of LOX and collagen I were closely associated with Gleason score and tumor stage. In addition, although LOX was expressed in cancer and non-cancer tissues, the differential expression pattern observed in the ECM of Pca cells may indicate that LOX is an important molecule that affects the progression of this disease. Therefore, LOX expression level in the ECM may function as an independent predictor of Pca.
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影响因子：
4
作者：
Grimsby, Jessica L.;Lucero, Hector A.;Trackman, Philip C.;Ravid, Katya;Kagan, Herbert M.
通讯作者：
Kagan, Herbert M.
影响因子：
6.6
作者：
Burns-Cox, N;Avery, NC;Bailey, AJ
通讯作者：
Bailey, AJ
影响因子：
3.7
作者：
Barcus CE;Holt EC;Keely PJ;Eliceiri KW;Schuler LA
通讯作者：
Schuler LA
影响因子：
5.2
作者：
Hase, Hiroaki;Jingushi, Kentaro;Tsujikawa, Kazutake
通讯作者：
Tsujikawa, Kazutake
影响因子：
4.3
作者：
Palladini, Giuseppina;Ferrigno, Andrea;Vairetti, Mariapia
通讯作者：
Vairetti, Mariapia