PHGDH as a mechanism for resistance in metabolically-driven cancers.
PHGDH as a mechanism for resistance in metabolically-driven cancers.
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DOI：
10.20517/cdr.2020.46
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Van Tine BA
中科院分区：
文献类型：
--
作者：
Rathore R;Schutt CR;Van Tine BA
癌症研究的前沿是对癌细胞内代谢重编程的快速发展的理解。对代谢抑制的快速适应使细胞进化并获得对靶向治疗的抗性，这使得治疗开发复杂但可以实现。3-磷酸甘油酸脱氢酶（PHGDH）是新生丝氨酸生物合成的限速酶，在多种癌症中高表达，包括乳腺癌、黑色素瘤和尤文氏肉瘤。这篇综述将探讨PHGDH在正常生物过程中的作用，导致PHGDH在癌症进展中的作用。随着对PHGDH表达促进癌症生长的分子机制的理解，我们将强调已知的由PHGDH生物学促进的癌症治疗耐药机制，并确定用PHGDH抑制剂对抗PHGDH驱动的耐药的途径，从而开发有效的代谢疗法。
At the forefront of cancer research is the rapidly evolving understanding of metabolic reprogramming within cancer cells. The expeditious adaptation to metabolic inhibition allows cells to evolve and acquire resistance to targeted treatments, which makes therapeutic exploitation complex but achievable. 3-phosphoglycerate dehydrogenase (PHGDH) is the rate-limiting enzyme of de novo serine biosynthesis and is highly expressed in a variety of cancers, including breast cancer, melanoma, and Ewing’s sarcoma. This review will investigate the role of PHGDH in normal biological processes, leading to the role of PHGDH in the progression of cancer. With an understanding of the molecular mechanisms by which PHGDH expression advances cancer growth, we will highlight the known mechanisms of resistance to cancer therapeutics facilitated by PHGDH biology and identify avenues for combatting PHGDH-driven resistance with inhibitors of PHGDH to allow for the development of effective metabolic therapies.
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影响因子：
11.4
作者：
Chng, W-J;Huang, G. F.;Chung, T. H.;Ng, S. B.;Gonzalez-Paz, N.;Troska-Price, T.;Mulligan, G.;Chesi, M.;Bergsagel, P. L.;Fonseca, R.
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9.8
作者：
Acuna-Hidalgo, Rocio;Schanze, Denny;Zenker, Martin
通讯作者：
Zenker, Martin
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作者：
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通讯作者：
Boussioutas A