Endoplasmic reticulum stress-induced PCD and caspase-like activities involved.
Endoplasmic reticulum stress-induced PCD and caspase-like activities involved.
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DOI：
10.3389/fpls.2014.00041
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发表时间：
2014
影响因子：
5.6
通讯作者：
Gallois P
中科院分区：
文献类型：
--
作者：
Cai YM;Yu J;Gallois P
植物细胞，像来自其他王国的细胞一样，具有以基因控制的方式自我毁灭的能力。这个过程被定义为程序性细胞死亡（PCD）。PCD可由植物内质网（ER）胁迫等多种刺激触发。过去二十年的研究发现，内质网蛋白稳态的破坏可能导致内质网应激，当内质网应激持续或未解决时，将导致细胞进入PCD。内质网胁迫诱导的PCD是几种植物过程的一部分，例如，干旱和热胁迫已被发现可引发内质网胁迫诱导的PCD。尽管内质网应激诱导的PCD在植物中很重要，但与动物细胞中的对应物相比，其调控在很大程度上仍然未知。在哺乳动物细胞中，发现几种促凋亡蛋白酶（称为caspase）在内质网应激诱导的PCD中起关键作用。在过去的十年中，在植物中发现了几种具有半胱天冬酶样酶活性的关键蛋白酶，这些蛋白酶与PCD调控有关。本文综述了植物内质网胁迫诱导PCD过程中caspase样酶活性的已知情况，并讨论了导致植物中相关蛋白酶激活的可能调控途径。
Plant cells, like cells from other kingdoms, have the ability to self-destruct in a genetically controlled manner. This process is defined as Programmed cell death (PCD). PCD can be triggered by various stimuli in plants including by endoplasmic reticulum (ER) stress. Research in the past two decades discovered that disruption of protein homeostasis in the ER could cause ER stress, which when prolonged/unresolved leads cells into PCD. ER stress-induced PCD is part of several plant processes, for instance, drought and heat stress have been found to elicit ER stress-induced PCD. Despite the importance of ER stress-induced PCD in plants, its regulation remains largely unknown, when compared with its counterpart in animal cells. In mammalian cells, several pro-apoptotic proteases called caspases were found to play a crucial role in ER stress-induced PCD. Over the past decade, several key proteases with caspase-like enzymatic activity have been discovered in plants and implicated in PCD regulation. This review covers what is known about caspase-like enzymatic activities during plant ER stress-induced PCD and discusses possible regulation pathways leading to the activation of relevant proteases in plants.
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影响因子：
16
作者：
Harding, HP;Zhang, YH;Ron, D
通讯作者：
Ron, D
影响因子：
3.7
作者：
Moreno AA;Mukhtar MS;Blanco F;Boatwright JL;Moreno I;Jordan MR;Chen Y;Brandizzi F;Dong X;Orellana A;Pajerowska-Mukhtar KM
通讯作者：
Pajerowska-Mukhtar KM
影响因子：
4.8
作者：
He, Rui;Drury, Georgina E.;Gallois, Patrick
通讯作者：
Gallois, Patrick
影响因子：
9.2
作者：
del Pozo, O;Lam, E
通讯作者：
Lam, E
影响因子：
11.6
作者：
Coffeen, WC;Wolpert, TJ
通讯作者：
Wolpert, TJ