Rebalancing binocular vision in amblyopia.
Rebalancing binocular vision in amblyopia.
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DOI：
10.1111/opo.12115
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发表时间：
2014-03
期刊：
影响因子：
--
通讯作者：
Levi DM
中科院分区：
文献类型：
--
作者：
Ding J;Levi DM
患有弱视的人在双眼视觉中具有不对称性：来自弱视眼的神经信号在皮层中被对侧眼抑制。本研究的目的是开发新的模型和方法，通过操纵双眼的对比度和亮度来重新平衡这种不对称的双眼视觉。我们通过询问正常和弱视的观察者来指示相对于黑色水平参考线的水平回旋正弦波中的暗槽的表观位置（相位）来测量回旋正弦波的感知相位，并且通过将双眼组合对比度与呈现给一只眼睛的标准对比度相匹配来使用相同的刺激来测量感知对比度。我们改变了两眼输入的相对对比度和亮度，以重新平衡不对称的双眼视觉。刺激对比度或空间频率越高，弱视双眼视觉变得越来越不对称。重新分析我们以前的数据，我们发现，在一个给定的空间频率，双目不对称性可以用一个对数线性公式与两个参数，一个最大的不对称性和一个的速率，在该双目系统成为不对称的对比度增加。我们的新数据表明，降低优势眼的平均亮度减少了对非优势眼的抑制，因此重新平衡了不对称的双眼视觉。虽然可以通过在给定的空间频率和对比度下操纵两只眼睛的相对对比度或亮度来重新平衡弱视视觉中的双眼不对称性，但是对于所有视觉条件重新平衡不对称性是非常困难的或者甚至是不可能的。尽管如此，在优势眼之前佩戴中性密度滤光片（或增加非优势眼的平均亮度）可能比传统的遮盖优势眼治疗弱视的方法更有益。
Humans with amblyopia have an asymmetry in binocular vision: neural signals from the amblyopic eye are suppressed in the cortex by the fellow eye. The purpose of this study was to develop new models and methods for rebalancing this asymmetric binocular vision by manipulating the contrast and luminance in the two eyes. We measured the perceived phase of a cyclopean sinewave by asking normal and amblyopic observers to indicate the apparent location (phase) of the dark trough in the horizontal cyclopean sine wave relative to a black horizontal reference line, and used the same stimuli to measure perceived contrast by matching the binocular combined contrast to a standard contrast presented to one eye. We varied both the relative contrast and luminance of the two eyes’ inputs, in order to rebalance the asymmetric binocular vision. Amblyopic binocular vision becomes more and more asymmetric the higher the stimulus contrast or spatial frequency. Reanalysing our previous data, we found that, at a given spatial frequency, the binocular asymmetry could be described by a log-linear formula with two parameters, one for the maximum asymmetry and one for the rate at which the binocular system becomes asymmetric as the contrast increases. Our new data demonstrates that reducing the dominant eye’s mean luminance reduces its suppression of the non-dominant eye, and therefore rebalances the asymmetric binocular vision. While the binocular asymmetry in amblyopic vision can be rebalanced by manipulating the relative contrast or luminance of the two eyes at a given spatial frequency and contrast, it is very difficult or even impossible to rebalance the asymmetry for all visual conditions. Nonetheless, wearing a neutral density filter before the dominant eye (or increasing the mean luminance in the non-dominant eye) may be more beneficial than the traditional method of patching the dominant eye for treating amblyopia.
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影响因子：
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