Invasive Haemophilus influenzae disease: changing epidemiology and host-parasite interactions in the 21st century.

Invasive Haemophilus influenzae disease: changing epidemiology and host-parasite interactions in the 21st century.
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侵袭性流感嗜血杆菌疾病:21 世纪不断变化的流行病学和宿主-寄生虫相互作用。

DOI:
10.1016/j.meegid.2009.03.001
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发表时间:
2009
期刊:
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases
影响因子:
--
通讯作者:
R. Tsang
R. Tsang
中科院分区:
--
文献类型:
--
作者:
M. Ulanova;R. Tsang

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20世纪80年代末至90年代初,在许多实施常规HiB免疫规划的工业化国家,B型流感嗜血杆菌(HiB)结合疫苗的引入对儿童侵袭性HiB疾病的发病率产生了显著影响。然而,疫苗失败的病例以及对侵袭性HiB和非B型H的易感性增加。在患有各种先天性和获得性免疫缺陷的个体中一直报告流感疾病。值得注意的是,在21世纪,由于非B型H.流感变得比以前更加频繁。尽管针对Hib的免疫接种总体上是成功的,但一些土著人口,即澳大利亚土著和北美印第安儿童的侵入性H.流行性感冒为了监测侵入性H.流感疾病,需要仔细记录的监测数据,以捕捉问题的真正严重性。开发针对非B H型的新疫苗。流感是保护一些脆弱人群免受这种侵袭性疾病侵害的一种潜在解决办法。
Introduction of Haemophilus influenzae type b (Hib) conjugate vaccines in late 1980s–early 1990s made a dramatic effect on the incidence of invasive Hib disease among children in many industrialized countries with routine Hib immunization programs. However, cases of vaccine failure and an increased susceptibility to invasive Hib as well as non-type b H. influenzae disease have been consistently reported among individuals with various congenital and acquired immunodeficiencies. Remarkably, in the 21st century, diseases due to non-type b strains of H. influenzae are becoming relatively more frequent than before. Despite the overall successful immunization against Hib, some indigenous populations, i.e. Australian Aboriginal and North American Indian children still experience increased rates of invasive H. influenzae disease. In order to monitor the evolving nature of invasive H. influenzae disease, carefully documented surveillance data is required to capture the true magnitude of the problem. Developing new vaccines against non-type b H. influenzae is a potential solution to protect some vulnerable populations against the invasive disease.
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