Neuropsychological Correlates of Pre-Frailty in Neurocognitive Disorders: A Possible Role for Metacognitive Dysfunction and Mood Changes.
Neuropsychological Correlates of Pre-Frailty in Neurocognitive Disorders: A Possible Role for Metacognitive Dysfunction and Mood Changes.
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DOI：
10.3389/fmed.2017.00199
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发表时间：
2017
影响因子：
3.9
通讯作者：
Rainero I
中科院分区：
文献类型：
--
作者：
Amanzio M;Palermo S;Zucca M;Rosato R;Rubino E;Leotta D;Bartoli M;Rainero I
最近的研究表明，神经认知障碍患者的认知功能在虚弱的发病机制中起着重要作用。虽然脆弱前期被认为是一种中间的临床前状态，但流行病学研究已经开始将认知和脆弱排除在其特定的亚成分中，以了解它们之间的关系。我们的目标是分析脆弱前期和神经心理变量之间的可能联系，以勾勒出哪些因素可以导致轻微和严重的神经认知障碍。60名抱怨不同认知缺陷的受试者接受了深入广泛的脆弱和神经心理学评估。我们进行了三次多元线性回归分析，调整了人口统计指标的组合，并涉及到几个神经心理-行为参数，这些参数是从有关身体虚弱的文献中选择的。我们发现，脆弱--通过多维预后指数(MPI)衡量--与行动监测和金钱收益(认知领域)、抑郁和去抑制(行为领域)之间存在显著关联。此外，MPI与工具性活动障碍意识受损之间存在关联。我们提出了一个新的框架来理解与元认知-执行功能障碍相关的脆弱性。
Recent studies have suggested that cognitive functions in patients with neurocognitive disorders have a significant role in the pathogenic mechanisms of frailty. Although pre-frailty is considered an intermediate, preclinical state, epidemiological research has begun to dislodge cognition and frailty into their specific subcomponents to understand the relationship among them. We aim to analyse the possible association between pre-frailty and neuropsychological variables to outline which factors can contribute to minor and major neurocognitive disorders. 60 subjects complaining of different cognitive deficits underwent a deep-in-wide frailty and neuropsychological assessment. We conducted three multiple linear regression analyses adjusted for a combination of demographic measures and involving several neuropsychological–behavioural parameters selected by the literature on physical frailty. We found a significant association between frailty—as measured by the multidimensional prognostic index (MPI)—and action monitoring and monetary gain (cognitive domain), depression and disinhibition (behavioural domain). Moreover, an association between MPI and impaired awareness for instrumental activities disabilities exists. We propose a novel framework for understanding frailty associated with metacognitive–executive dysfunction.
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影响因子：
4.8
作者：
Assal, F;Cummings, JL
通讯作者：
Cummings, JL
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4
作者：
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14.5
作者：
DERENZI, E;VIGNOLO, LA
通讯作者：
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作者：
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通讯作者：
Lopiano, Leonardo
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3.3
作者：
Fougere, Bertrand;Delrieu, Julien;Vellas, Bruno
通讯作者：
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