Magnetic resonance imaging detects placental hypoxia and acidosis in mouse models of perturbed pregnancies.
Magnetic resonance imaging detects placental hypoxia and acidosis in mouse models of perturbed pregnancies.
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磁共振成像检测扰乱妊娠小鼠模型中的胎盘缺氧和酸中毒。
DOI：
10.1371/journal.pone.0059971
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Hennessy A
中科院分区：
文献类型：
--
作者：
Bobek G;Stait-Gardner T;Surmon L;Makris A;Lind JM;Price WS;Hennessy A
胎盘分泌的抗血管生成分子失调导致的内皮功能障碍导致孕妇高血压反应，这是子痫前期妊娠并发症的特征。胎盘结构异常可导致胎盘灌注改变、胎盘氧化应激、细胞损伤和炎症以及抗血管生成化合物释放到母体循环中。这些因素之间的确切联系尚不清楚。在这里，我们表明，使用磁共振成像作为工具来检查胎盘变化的小鼠模型的妊娠，胎盘的不同区域之间的t2对比在血流完全丧失时被消除。t2（自旋-自旋或横向）弛豫时间的改变被解释为组织内缺氧和酸中毒的结果。在异常妊娠中也观察到类似的变化，表明酸中毒和缺氧可能是妊娠并发症（如子痫前期）的一个特征，并可能在导致抗血管生成化合物分泌增加的信号通路中发挥重要作用。
Endothelial dysfunction as a result of dysregulation of anti-angiogenic molecules secreted by the placenta leads to the maternal hypertensive response characteristic of the pregnancy complication of preeclampsia. Structural abnormalities in the placenta have been proposed to result in altered placental perfusion, placental oxidative stress, cellular damage and inflammation and the release of anti-angiogenic compounds into the maternal circulation. The exact link between these factors is unclear. Here we show, using Magnetic Resonance Imaging as a tool to examine placental changes in mouse models of perturbed pregnancies, that T 2 contrast between distinct regions of the placenta is abolished at complete loss of blood flow. Alterations in T 2 (spin-spin or transverse) relaxation times are explained as a consequence of hypoxia and acidosis within the tissue. Similar changes are observed in perturbed pregnancies, indicating that acidosis as well as hypoxia may be a feature of pregnancy complications such as preeclampsia and may play a prominent role in the signalling pathways that lead to the increased secretion of anti-angiogenic compounds.
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影响因子：
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作者：
Gowland, P
通讯作者：
Gowland, P
DOI：
10.1152/ajpregu.00794.2005
发表时间：
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