Patient's global assessment of disease activity and patient's assessment of general health for rheumatoid arthritis activity assessment: are they equivalent?
Patient's global assessment of disease activity and patient's assessment of general health for rheumatoid arthritis activity assessment: are they equivalent?
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DOI：
10.1136/annrheumdis-2011-201142
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发表时间：
2012-12
影响因子：
27.4
通讯作者：
QUEST-RA group
中科院分区：
文献类型：
--
作者：
Khan NA;Spencer HJ;Abda EA;Alten R;Pohl C;Ancuta C;Cazzato M;Géher P;Gossec L;Henrohn D;Hetland ML;Inanc N;Jacobs JW;Kerzberg E;Majdan M;Oyoo O;Peredo-Wende RA;Selim ZI;Skopouli FN;Sulli A;Hørslev-Petersen K;Taylor PC;Sokka T;QUEST-RA group
评估(A)类风湿性关节炎(RA)患者的疾病活动总体评估(PTGL)和患者总体健康评估(GH)评分的决定因素；(B)它们是否等同于个体变量；以及(C)它们是否可以互换用于计算共同的RA活动评估综合指数。对来自30个国家和地区的7023例类风湿性关节炎患者的量化标准监测(QUEST-RA)数据进行了分析。通过协方差模型的混合效应分析评估PTGL和GH决定因素。用Bland-Altman 95%一致性限(BALOA)和林氏一致性系数(LCC)确定PTGL和GH的等效性。用LCC计算PTGL和GH疾病活动评分28(DAS28)、临床疾病活动指数(CDAI)和常规患者指数数据评估3(RAPID3)指数的一致性，并用κ统计方法计算四种状态(缓解、低、中、高)RA活动分类的一致性程度。在PTGL和GH分级中，RA和非RA相关变量的相对和绝对贡献有显著差异。LCC值为0.64，BALOA值为4.41~4.54，表明−和GH不是等价性的。以Ptgl和GH为基础的DAS28、CDAi和RAPID3指数在RA活动状态分类中具有极好的一致性(LCC0.95-0.99)，而在RA活动状态分类中这三个指数的绝对符合率为80%(κ统计量为0.75-0.84)。PTGL和GH评级的决定因素不同。尽管它们各自不是等价的，但它们可以互换地用于计算RA活动评估的综合指数。
To assess (A) determinants of patient’s global assessment of disease activity (PTGL) and patient’s assessment of general health (GH) scores of rheumatoid arthritis (RA) patients; (B) whether they are equivalent as individual variables; and (C) whether they may be used interchangeably in calculating common RA activity assessment composite indices. Data of 7023 patients from 30 countries in the Quantitative Standard Monitoring of Patients with RA (QUEST-RA) was analysed. PTGL and GH determinants were assessed by mixed-effects analyses of covariance models. PTGL and GH equivalence was determined by Bland-Altman 95% limits of agreement (BALOA) and Lin’s coefficient of concordance (LCC). Concordance between PTGL and GH based Disease Activity Score 28 (DAS28), Clinical Disease Activity Index (CDAI) and Routine Assessment of Patient Index Data 3 (RAPID3) indices were calculated using LCC, and the level of agreement in classifying RA activity in four states (remission, low, moderate, high) using κ statistics. Significant differences in relative and absolute contribution of RA and non-RA related variables in PTGL and GH ratings were noted. LCC of 0.64 and BALOA of −4.41 to 4.54 showed that PTGL and GH are not equivalent. There was excellent concordance (LCC 0.95–0.99) for PTGL and GH based DAS28, CDAI and RAPID3 indices, and >80% absolute agreement (κ statistics 0.75–0.84) in RA activity state classification for all three indices. PTGL and GH ratings differ in their determinants. Although they are individually not equivalent, they may be used interchangeably for calculating composite indices for RA activity assessment.
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影响因子：
4.9
作者：
Aletaha D;Nell VP;Stamm T;Uffmann M;Pflugbeil S;Machold K;Smolen JS
通讯作者：
Smolen JS
影响因子：
27.4
作者：
Koevoets, R.;Klarenbeek, N. B.;Allaart, C. F.
通讯作者：
Allaart, C. F.
DOI：
10.1016/j.berh.2007.02.005
发表时间：
2007-08-01
影响因子：
5.2
作者：
Pincus, Theodore;Yazici, Yusuf;Bergman, Martin
通讯作者：
Bergman, Martin
影响因子：
3.9
作者：
Hirsh, Joel M.;Boyle, Dennis J.;Caplan, Liron
通讯作者：
Caplan, Liron
影响因子：
27.4
作者：
Gossec, L.;Paternotte, S.;Kvien, T. K.
通讯作者：
Kvien, T. K.