Medical comorbidity and distress in patients with irritable bowel syndrome: The moderating role of age.
Medical comorbidity and distress in patients with irritable bowel syndrome: The moderating role of age.
复制标题
肠易激综合征患者的医疗合并症和痛苦：年龄的调节作用。
DOI：
10.1016/j.jpsychores.2016.07.006
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发表时间：
2016
影响因子：
4.7
通讯作者：
Lackner,JeffreyM
中科院分区：
文献类型：
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作者：
Thakur,ElyseR;Quigley,BrianM;El-Serag,HashemB;Gudleski,GregoryD;Lackner,JeffreyM
目的肠易激综合征（IBS）影响各个年龄段的人，并与其他疾病高度共病。本研究的目的是确定年龄对肠易激综合征患者医疗合并症和健康结局之间关系的调节作用。方法年龄范围（18 - 70岁）的384名患者完成了关于医疗合并症、焦虑、抑郁、IBS症状严重程度和IBS生活质量（QOL）的问卷调查。结果患者平均年龄41岁（SD= 15）。年龄与医疗合并症相互作用预测焦虑，F(7,354) = 5.82,p= 0.009,R2= 0.10。结果显示：教育程度（β= - 0.16,p< 0.05）、年龄（β= - 0.15,p< 0.05）、医疗合并症（β= 0.25,p< 0.05）和相互作用（β= - 0.15,p< 0.01）显著。在有许多合并症的患者中，焦虑更大，这种影响在年轻人中更为明显。抑郁症，也可以通过年龄和合并症之间的相互作用来预测，表现出与焦虑相同的模式。在预测IBS症状严重程度或IBS生活质量方面，年龄和医疗合并症之间没有显著的相互作用。结论伴有内科合并症的IBS患者的痛苦程度随年龄而变化，年轻人的焦虑和抑郁水平高于老年人。与IBS症状严重程度和年轻IBS患者的生活质量相比，医学共病可能对心理困扰有更多的选择性影响。焦虑可能会增加这些患者的肠易激综合征负担，并使其医疗管理复杂化。
ObjectivesIrritable bowel syndrome (IBS) affects people across the age spectrum and is highly comorbid with other medical conditions. The aim of this study was to determine the moderating effect of age on the relationship between medical comorbidity and health outcomes in IBS patients.MethodsPatients (n= 384) across the age spectrum (18 to 70) completed questionnaires regarding medical comorbidities, anxiety, depression, IBS symptom severity, and IBS quality of life (QOL).ResultsThe mean age was 41 (SD= 15). Age interacted with medical comorbidities to predict anxiety,F(7,354) = 5.82,p= 0.009,R2= 0.10. Results revealed significant main effects for education,β= − 0.16,p< 0.05, age,β= − 0.15,p< 0.05, medical comorbidities,β= 0.25,p< 0.05, and a significant interaction,β= − 0.15,p< 0.01. Anxiety was greater among patients with many comorbidities, with this effect being more pronounced for younger adults. Depression, also predicted by the interaction between age and comorbidities, showed the same pattern as anxiety. There was no significant interaction between age and medical comorbidities in predicting IBS symptom severity or IBS QOL.ConclusionDistress among IBS patients with medical comorbidities varies with age, with higher levels of anxiety and depression among younger adults than their older counterparts. Medical comorbidity may have a more selective impact on psychological distress as compared to IBS symptom severity and quality of life for younger adults with IBS. Distress may increase IBS burden for these patients and complicate its medical management.
影响因子：
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作者：
Kessler, RC;Berglund, P;Walters, EE
通讯作者：
Walters, EE