Differential effects of Akkermansia-enriched fecal microbiota transplant on energy balance in female mice on high-fat diet.
Differential effects of Akkermansia-enriched fecal microbiota transplant on energy balance in female mice on high-fat diet.
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DOI：
10.3389/fendo.2022.1010806
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发表时间：
2022
影响因子：
5.2
通讯作者：
Tetel, Marc J.
中科院分区：
文献类型：
--
作者：
Acharya, Kalpana D.;Friedline, Randall H.;Ward, Doyle V.;Graham, Madeline E.;Tauer, Lauren;Zheng, Doris;Hu, Xiaodi;de Vos, Willem M.;McCormick, Beth A.;Kim, Jason K.;Tetel, Marc J.
雌激素可以防止女性和雌性啮齿动物的体重增加和代谢紊乱。肠道微生物群组成的异常与肥胖和代谢紊乱有关。此外，雌激素介导的针对饮食诱导的代谢破坏的保护作用与肠道微生物群的改变有关。在这项研究中，我们测试了雌二醇（E2）介导的对雌性小鼠肥胖和代谢紊乱的保护是否依赖于肠道微生物群。具体而言，我们测试了来自E2处理的瘦雌性小鼠的粪便微生物群移植（FMT），补充有或没有嗜粘蛋白阿克曼氏菌，是否预防了高脂饮食（HFD）诱导的体重增加、脂肪量增加和雌性受体中的高血糖症。FMT，并与E2治疗瘦捐助者共居不足以转移代谢的好处，E2缺乏的女性收件人。此外，来自瘦供体的FMT补充A.嗜粘蛋白菌加重了E2缺乏受体中HFD诱导的高血糖症，表明其对喂食HFD的E2缺乏雌性啮齿动物的代谢健康的有害影响。鉴于A.虽然嗜粘蛋白菌减弱了男性中HFD诱导的代谢损伤，但本研究结果表明这种微生物对代谢健康的影响存在性别差异。
Estrogens protect against weight gain and metabolic disruption in women and female rodents. Aberrations in the gut microbiota composition are linked to obesity and metabolic disorders. Furthermore, estrogen-mediated protection against diet-induced metabolic disruption is associated with modifications in gut microbiota. In this study, we tested if estradiol (E2)-mediated protection against obesity and metabolic disorders in female mice is dependent on gut microbiota. Specifically, we tested if fecal microbiota transplantation (FMT) from E2-treated lean female mice, supplemented with or without Akkermansia muciniphila, prevented high fat diet (HFD)-induced body weight gain, fat mass gain, and hyperglycemia in female recipients. FMT from, and cohousing with, E2-treated lean donors was not sufficient to transfer the metabolic benefits to the E2-deficient female recipients. Moreover, FMT from lean donors supplemented with A. muciniphila exacerbated HFD-induced hyperglycemia in E2-deficient recipients, suggesting its detrimental effect on the metabolic health of E2-deficient female rodents fed a HFD. Given that A. muciniphila attenuates HFD-induced metabolic insults in males, the present findings suggest a sex difference in the impact of this microbe on metabolic health.
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影响因子：
4.6
作者：
Chen M;Cheng KW;Chen YJ;Wang CH;Cheng TC;Chang KC;Kao AP;Chuang KH
通讯作者：
Chuang KH
影响因子：
3.2
作者：
Bless EP;Reddy T;Acharya KD;Beltz BS;Tetel MJ
通讯作者：
Tetel MJ
影响因子：
15.5
作者：
D'Amato A;Di Cesare Mannelli L;Lucarini E;Man AL;Le Gall G;Branca JJV;Ghelardini C;Amedei A;Bertelli E;Regoli M;Pacini A;Luciani G;Gallina P;Altera A;Narbad A;Gulisano M;Hoyles L;Vauzour D;Nicoletti C
通讯作者：
Nicoletti C
影响因子：
2.8
作者：
de Vos, Willem M.
通讯作者：
de Vos, Willem M.
影响因子：
4.6
作者：
Dashnyam P;Mudududdla R;Hsieh TJ;Lin TC;Lin HY;Chen PY;Hsu CY;Lin CH
通讯作者：
Lin CH