Monoclonal antibodies against carbohydrate differentiation antigens identify subsets of primary sensory neurones
Monoclonal antibodies against carbohydrate differentiation antigens identify subsets of primary sensory neurones
复制标题
针对碳水化合物分化抗原的单克隆抗体可识别初级感觉神经元的亚群
作者：
J. Dodd;D. Solter;T. Jessell
背根神经节（DRG）神经元将皮肤感觉信息从外周传递到脊髓。在脊髓的背角内，由不同皮肤刺激激活的感觉纤维类终止于单独且高度限制的层1 -3。虽然尚未定义的感觉传入末梢的层状组织的发展事件，它是可能的，DRG和背角神经元的表面分子之间的相互作用参与传入突触连接的产生。识别区分DRG神经元功能亚类的表面抗原将代表建立此类分子的存在和性质的第一步。我们在这里报告，针对碳水化合物分化抗原的单克隆抗体4，5识别选择性表达的DRG神经元的功能亚群的细胞质和细胞表面分子。
Dorsal root ganglion (DRG) neurones transmit cutaneous sensory information from the periphery to the spinal cord. Within the dorsal horn of the spinal cord, classes of sensory fibres that are activated by different cutaneous stimuli terminate in separate and highly restricted laminae1–3. Although the developmental events resulting in the laminar organization of sensory afferent terminals have not been defined, it is likely that interactions between surface molecules on DRG and dorsal horn neurones are involved in the generation of afferent synaptic connections. The identification of surface antigens that distinguish functional subclasses of DRG neurones would represent a first step in establishing the existence and nature of such molecules. We report here that monoclonal antibodies directed against carbohydrate differentiation antigens4,5 identify cytoplasmic and cell surface molecules expressed selectively by functional subsets of DRG neurones.
人类畸胎瘤中的新球系列鞘糖脂可与针对发育调节抗原（阶段特异性胚胎抗原 3）的单克隆抗体发生反应。
DOI：
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发表时间：
1983
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Kannagi,R;Levery,SB;Ishigami,F;Hakomori,S;Shevinsky,LH;Knowles,BB;Solter,D
通讯作者：
Solter,D
神经细胞粘附分子的分子和生物学特性。
DOI：
10.1101/sqb.1983.048.01.055
发表时间：
1983
期刊：
Cold Spring Harbor symposia on quantitative biology
影响因子：
--
作者：
Rutishauser,U
通讯作者：
Rutishauser,U