Small and large animal models in cardiac contraction research: advantages and disadvantages.
Small and large animal models in cardiac contraction research: advantages and disadvantages.
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DOI：
10.1016/j.pharmthera.2013.10.007
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发表时间：
2014-03
影响因子：
13.5
通讯作者：
Janssen, Paul M. L.
中科院分区：
文献类型：
--
作者：
Milani-Nejad, Nima;Janssen, Paul M. L.
哺乳动物的心脏不仅负责将血液输送到全身，而且还负责根据身体代谢需求的突然变化迅速调整这种输送活动。在大多数情况下，人类的心脏能够毫不费力地履行自己的职责；然而，经过几十年的使用，这个系统在某些时候遇到了问题。为了制定新的治疗方案，最终延长和改善患者的生命，研究健康状态和疾病状态下的心脏活动是必要的。动物模型是心脏研究的一个重要方面，可以研究各种心脏过程和治疗靶点。然而，人类的心脏和动物的心脏是不同的，根据特定的动物，这些差异会变得更加明显，在某些情况下是有限的。没有理想的动物模型可用于心脏研究，每种动物模型的使用都伴随着其自身的一套优点和缺点。在这篇综述中，我们将讨论这些常用的实验动物的优缺点，包括小鼠、大鼠、兔、犬、猪和羊。由于心脏研究的目标是提高我们对人类健康和疾病的理解，并帮助改善临床结果，我们也将讨论人类心脏组织在心脏研究中的作用。这篇综述将集中在人类和动物模型的心室收缩和松弛动力学上，以说明这些差异。
The mammalian heart is responsible for not only pumping blood throughout the body but also adjusting this pumping activity quickly depending upon sudden changes in the metabolic demands of the body. For the most part, the human heart is capable of performing its duties without complications; however, throughout many decades of use, at some point this system encounters problems. Research into the heart’s activities during healthy states and during adverse impacts that occur in disease states is necessary in order to strategize novel treatment options to ultimately prolong and improve patients’ lives. Animal models are an important aspect of cardiac research where a variety of cardiac processes and therapeutic targets can be studied. However, there are differences between the heart of a human being and an animal and depending on the specific animal, these differences can become more pronounced and in certain cases limiting. There is no ideal animal model available for cardiac research, the use of each animal model is accompanied with its own set of advantages and disadvantages. In this review, we will discuss these advantages and disadvantages of commonly used laboratory animals including mouse, rat, rabbit, canine, swine, and sheep. Since the goal of cardiac research is to enhance our understanding of human health and disease and help improve clinical outcomes, we will also discuss the role of human cardiac tissue in cardiac research. This review will focus on the cardiac ventricular contractile and relaxation kinetics of humans and animal models in order to illustrate these differences.
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DOI：
10.1161/circheartfailure.110.959684
发表时间：
2011-03
期刊：
Circulation. Heart failure
影响因子：
--
作者：
Ambardekar AV;Buttrick PM
通讯作者：
Buttrick PM
DOI：
10.1152/ajpheart.00274.2002
发表时间：
2002-10-01
影响因子：
4.8
作者：
Alpert, NR;Brosseau, C;Warshaw, DM
通讯作者：
Warshaw, DM
DOI：
10.1111/j.1540-8167.2007.00963.x
发表时间：
2007-12-01
影响因子：
2.7
作者：
Allison, J. Scott;Qin, Hao;Ideker, Raymond E.
通讯作者：
Ideker, Raymond E.
DOI：
10.1007/3-540-26574-0_7
发表时间：
2005-01-01
期刊：
PRACTICAL METHODS IN CARDIOVASCULAR RESEARCH
影响因子：
--
作者：
Billman, GE
通讯作者：
Billman, GE
影响因子：
--
作者：
BOLTER, CP;ATKINSON, KJ
通讯作者：
ATKINSON, KJ