Ingestible electronic sensors to measure instantaneous medication adherence: A narrative review.
Ingestible electronic sensors to measure instantaneous medication adherence: A narrative review.
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DOI：
10.1177/20552076221083119
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发表时间：
2022-01
期刊：
影响因子：
3.9
通讯作者：
O'Cleirigh C
中科院分区：
文献类型：
--
作者：
Chai PR;Vaz C;Goodman GR;Albrechta H;Huang H;Rosen RK;Boyer EW;Mayer KH;O'Cleirigh C
药物不依从性导致全球范围内的显著发病率和死亡率。虽然存在许多测量依从性的技术，但数字药丸系统代表了测量依从性的新颖、直接的方法和提供即时依从性支持的手段。在这篇叙述性综述中，我们讨论了数字药丸系统研究的基础上进行的临床试验和定性调查的日期和潜在的未来应用的数字药丸系统在服药依从性测量。我们在PubMed中进行了一项文献检索，检索了2000年至2021年期间描述使用数字药丸系统测量药物依从性的英文同行评审文章。我们纳入了所有描述可摄入传感器部署的文章，以及涉及对人类受试者进行数字药丸系统定性研究的文章。初次检索共发现95篇文章;根据排除标准删除了75篇。纳入的文章被分类为在人群中部署可摄入传感器的研究（n = 18）或进行定性工作的研究（n = 3）。对于试点研究，传感器成功检测药物摄入事件的平均准确度范围为68%至100%。当数字药丸系统部署在现实世界的临床环境中时，准确度范围从68%到90%，由于不遵守数字药丸系统技术，准确度较低。定性研究表明，供应商和患者认为数字药丸系统是提高依从性的促进者，也是提供依从性干预措施的潜在平台。此外，来自数字药丸系统的摄入数据被认为有助于促进临床医生和患者之间的依从性讨论。该叙述性综述表明，数字药丸系统的使用在多种疾病状态下广泛可行，包括人类免疫缺陷病毒、丙型肝炎感染、实体器官移植、结核病、精神分裂症、心血管疾病和急性骨折，其中依从性与显著的发病率和死亡率密切相关。它还强调了在大规模临床部署此类系统之前仍然需要研究的关键领域。
Medication nonadherence contributes to significant morbidity and mortality worldwide. While many techniques to measure adherence exist, digital pill systems represent a novel, direct method of measuring adherence and a means of providing instantaneous adherence supports. In this narrative review, we discuss digital pill system research based on clinical trials and qualitative investigations conducted to date and potential future applications of digital pill system in medication adherence measurement. We conducted a literature search in PubMed of English language peer-reviewed articles describing the use of digital pill system for medication adherence measurement between 2000 and 2021. We included all articles that described the deployment of ingestible sensors and those involving qualitative investigations of digital pill system with human subjects. A total of 95 articles were found on initial search; 75 were removed based on exclusion criteria. Included articles were categorized as investigations that deployed an ingestible sensor in human populations (n = 18), or those that conducted qualitative work (n = 3). For pilot studies, the mean accuracy of the sensor to successfully detect a medication ingestion event ranged from 68% to 100%. When digital pill systems were deployed in real-world clinical settings, accuracy ranged from 68% to 90% with lower accuracy due to nonadherence to digital pill system technology. Qualitative studies demonstrated that providers and patients perceive the digital pill system as a facilitator for improving adherence and as a potential platform for delivering adherence interventions. Additionally, ingestion data from digital pill system was viewed as useful in facilitating adherence discussions between clinicians and patients. This narrative review demonstrates that the use of digital pill system is broadly feasible across multiple disease states including human immunodeficiency virus, hepatitis C infection, solid organ transplants, tuberculosis, schizophrenia, cardiovascular disease, and acute fractures, where adherence is closely linked to significant morbidity and mortality. It also highlights key areas of research that are still needed prior to broad-scale clinical deployment of such systems.
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DOI：
10.3390/s18072183
发表时间：
2018-07-06
期刊：
Sensors (Basel, Switzerland)
影响因子：
--
作者：
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影响因子：
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影响因子：
3.7
作者：
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影响因子：
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影响因子：
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