Frailty and incident heart failure in older men: the British Regional Heart Study.
Frailty and incident heart failure in older men: the British Regional Heart Study.
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老年男性的虚弱和心力衰竭：英国区域心脏研究。
DOI：
10.1136/openhrt-2021-001571
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发表时间：
2021-06
期刊：
影响因子：
2.7
通讯作者：
Wannamethee SG
中科院分区：
文献类型：
--
作者：
McKechnie DG;Papacosta AO;Lennon LT;Ramsay SE;Whincup PH;Wannamethee SG
虚弱和心力衰竭（HF）在横断面上相关。发表的纵向数据非常有限。我们试图调查虚弱和HF事件之间的关系。对1722名72-91岁男性进行的前瞻性研究。计算了基于Fried表型、Gill指数和基于健康老龄化和身体成分组合的新型虚弱评分的评分，其中包括缓慢的步行速度、低椅子站立时间和平衡的主观困难。采用考克斯比例风险模型分析这些评分与HF事件之间的关系。纳入了1445例有虚弱数据且无流行性HF的男性。99例发生HF（平均随访6.1年）。在我们的新虚弱评分中得分为3/3的男性发生HF的风险升高（HR 2.77，95% CI 1.25至6.15），在调整了已确定的风险因素和白细胞介素-6后仍持续存在（HR 3.14，95% CI 1.35至7.31）。在排除基线后2年内的HF事件后，该风险仍然增加，尽管减弱（HR 2.05，95% CI 0.61 - 6.92）。虚弱表型显示与HF无显著相关性（年龄校正HR 1.92，95% CI 0.99 - 3.73），在校正普遍冠心病和体重指数后进一步减弱（HR 1.60，95% CI 0.81 - 3.15）。在这些调整后，Gill型评分与HF风险弱相关（HR 1.31，95% CI 0.47至3.70）。在这些老年男性中，缓慢的步行速度、较短的坐立时间和平衡问题的组合与HF事件的高风险相关，独立于已确定的风险因素和炎症标志物。然而，基线时未诊断的HF可能仍然是混杂因素。虚弱表型和HF事件之间存在差异性关联。
Frailty and heart failure (HF) are cross-sectionally associated. Published longitudinal data are very limited. We sought to investigate associations between frailty and incident HF. Prospective study of 1722 men, examined at age 72–91 years. Scores based on the Fried phenotype, Gill index and a novel frailty score, based on the Health Ageing and Body Composition Battery, incorporating slow walking speed, low chair-stand time and subjective difficulty with balance, were calculated. Associations between these scores and incident HF were analysed with Cox proportional hazard modelling. 1445 men with frailty data and without prevalent HF were included. 99 developed HF (mean follow-up 6.1 years). Men scoring 3/3 on our novel frailty score had elevated risk of incident HF (HR 2.77, 95% CI 1.25 to 6.15), which persisted after adjustment for established risk factors and interleukin-6 (HR 3.14, 95% CI 1.35 to 7.31). This risk remained increased, although attenuated, after excluding HF events within 2 years of baseline (HR 2.05, 95% CI 0.61 to 6.92). The frailty phenotype showed a non-significant association with HF (age-adjusted HR 1.92, 95% CI 0.99 to 3.73), which was further attenuated after adjustment for prevalent coronary heart disease and Body mass index (HR 1.60, 95% CI 0.81 to 3.15). Gill-type scores were weakly associated with HF risk after these adjustments (HR 1.31, 95% CI 0.47 to 3.70). In these older men, the combination of slow walk speed, low sit-stand time and balance problems were associated with high risk of incident HF, independent of established risk factors and inflammatory markers. However, undiagnosed HF at baseline may still be a confounder. There is a differential association between aspects of the frailty phenotype and incident HF.
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在加拿大健康措施调查中，加拿大人18-79岁的脆弱率。
影响因子：
4.1
作者：
Kehler DS;Ferguson T;Stammers AN;Bohm C;Arora RC;Duhamel TA;Tangri N
通讯作者：
Tangri N
影响因子：
1.8
作者：
TEASDALE, N;BARD, C;FLEURY, M
通讯作者：
FLEURY, M
影响因子：
3.5
作者：
Tiedemann, A;Sherrington, C;Lord, SR
通讯作者：
Lord, SR
影响因子：
4
作者：
Klein, BEK;Klein, R;Lee, KE
通讯作者：
Lee, KE
影响因子：
0.5
作者：
Bohannon, Richard W.
通讯作者：
Bohannon, Richard W.