Expanding the Paradigm: Intrinsically Disordered Proteins and Allosteric Regulation.
Expanding the Paradigm: Intrinsically Disordered Proteins and Allosteric Regulation.
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DOI：
10.1016/j.jmb.2018.04.003
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发表时间：
2018-08-03
影响因子：
5.6
通讯作者：
Wright PE
中科院分区：
文献类型：
--
作者：
Berlow RB;Dyson HJ;Wright PE
变构调节过程涉及所有水平的生物功能。近年来，我们对内在无序蛋白的多样性和功能上的重要类别的理解取得了进展，已经确定了无序蛋白在变构范式范围内发挥功能的多种方式。内在无序蛋白内部的变构或由其介导的变构确保了通过对球状蛋白相互作用伙伴极其不利甚至不可能的机制进行稳健和有效的信号整合。在这里，我们强调了最近的例子，表明生物结果的广度可以通过内在无序蛋白的变构调节来实现。在这个快速发展的研究领域正在进行的和未来的工作将扩大我们对内在无序蛋白在确保细胞调节的保真度和效率方面的核心作用的认识。
Allosteric regulatory processes are implicated at all levels of biological function. Recent advances in our understanding of the diverse and functionally significant class of intrinsically disordered proteins have identified a multitude of ways in which disordered proteins function within the confines of the allosteric paradigm. Allostery within or mediated by intrinsically disordered proteins ensures robust and efficient signal integration through mechanisms that would be extremely unfavorable or even impossible for globular protein interaction partners. Here, we highlight recent examples that indicate the breadth of biological outcomes that can be achieved through allosteric regulation by intrinsically disordered proteins. Ongoing and future work in this rapidly evolving area of research will expand our appreciation of the central role of intrinsically disordered proteins in ensuring the fidelity and efficiency of cellular regulation.
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影响因子：
7.2
作者：
Balagopalan, Lakshmi;Coussens, Nathan P.;Sommers, Connie L.
通讯作者：
Sommers, Connie L.
影响因子：
4
作者：
Bruschweiler, Sven;Konrat, Robert;Tollinger, Martin
通讯作者：
Tollinger, Martin
影响因子：
5.6
作者：
De Guzman, RN;Goto, NK;Wright, PE
通讯作者：
Wright, PE
DOI：
10.1073/pnas.93.23.12969
发表时间：
1996-11-12
影响因子：
11.1
作者：
Arany, Z;Huang, LE;Livingston, DM
通讯作者：
Livingston, DM
影响因子：
14.8
作者：
Borcherds, Wade;Theillet, Francois-Xavier;Daughdrill, Gary W.
通讯作者：
Daughdrill, Gary W.