An MHC class I immune evasion gene of Marek׳s disease virus.
An MHC class I immune evasion gene of Marek׳s disease virus.
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DOI：
10.1016/j.virol.2014.11.008
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发表时间：
2015-01-15
期刊：
影响因子：
3.7
通讯作者：
York, Ian A.
中科院分区：
文献类型：
--
作者：
Hearn, Cari;Preeyanon, Likit;Hunt, Henry D.;York, Ian A.
Marek’s Disease Virus (MDV) is a widespread α-herpesvirus of chickens that causes T cell tumors. Acute, but not latent, MDV infection has previously been shown to lead to downregulation of cell-surface MHC class I (Virology 282:198–205 (2001)), but the gene(s) involved have not been identified. Here we demonstrate that an MDV gene, MDV012, is capable of reducing surface expression of MHC class I on chicken cells. Co-expression of an MHC class I-binding peptide targeted to the endoplasmic reticulum (bypassing the requirement for the TAP peptide transporter) partially rescued MHC class I expression in the presence of MDV012, suggesting that MDV012 is a TAP-blocking MHC class I immune evasion protein. This is the first unique non-mammalian MHC class I immune evasion gene identified, and suggests that α-herpesviruses have conserved this function for at least 100 million years.
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DOI：
10.4049/jimmunol.0803663
发表时间：
2009-11-01
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Hearn A;York IA;Rock KL
通讯作者：
Rock KL
影响因子：
3.7
作者：
Hunt, HD;Lupiani, B;Parcells, MS
通讯作者：
Parcells, MS
影响因子：
4.4
作者：
Gold, MC;Munks, MW;Hill, AB
通讯作者：
Hill, AB
影响因子：
14.9
作者：
Hebsgaard, SM;Korning, PG;Brunak, S
通讯作者：
Brunak, S
DOI：
10.1084/jem.20070256
发表时间：
2007-08-06
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Hislop AD;Ressing ME;van Leeuwen D;Pudney VA;Horst D;Koppers-Lalic D;Croft NP;Neefjes JJ;Rickinson AB;Wiertz EJ
通讯作者：
Wiertz EJ