Significant association between the Axin2 rs2240308 single nucleotide polymorphism and the incidence of prostate cancer.
Significant association between the Axin2 rs2240308 single nucleotide polymorphism and the incidence of prostate cancer.
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Axin2 rs2240308单核苷酸多态性与前列腺癌发病率显着相关
DOI：
10.3892/ol.2014.2177
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发表时间：
2014-08
期刊：
影响因子：
2.9
通讯作者：
Watanabe M
中科院分区：
文献类型：
--
作者：
Ma C;Liu C;Huang P;Kaku H;Chen J;Guo K;Ueki H;Sakai A;Nasu Y;Kumon H;Shimizu K;Watanabe M
Wnt信号通路在人类癌症发展中起着至关重要的作用，轴抑制蛋白2（Axin2）是参与Wnt信号传导的主要支架蛋白。 Axin2 负向调节 Wnt 信号传导并充当肿瘤抑制蛋白。本研究评估了 Axin2 单核苷酸多态性 (SNP) rs2240308 [鸟嘌呤 (G)/腺嘌呤 (A)] 与前列腺癌发病率之间的关联。这项病例对照研究总共纳入了 103 名前列腺癌患者和 100 名无癌症对照男性，并使用从外周血样本中提取的基因组 DNA 进行了基因分型。结果显示，具有纯合GG基因型的受试者的前列腺癌发病率较高，而具有Axin2基因中rs2240308 SNP (G/A)的GA基因型的患者的前列腺癌发病率较低。与GG基因型相比，GA基因型携带者的调整后优势比为0.377（95% CI，0.206-0.688；P=0.001），AA基因型携带者的调整优势比为0.830（95% CI，0.309-2.232；P=0.712）。因此，发现 GA 基因型具有降低前列腺癌风险的保护作用。据我们所知，这是第一项证明该 SNP（rs2240308，G/A）与前列腺癌风险之间存在显着关联的研究。这种关联表明 Axin2 基因该位置的变异可能在促进前列腺癌的发展中发挥重要作用。我们相信 Axin2 SNP (rs2240308) 可能是该疾病易感性和早期诊断的有用生物标志物。
The Wnt signaling pathway plays a crucial role in human cancer development, and axis inhibition protein 2 (Axin2) is a master scaffold protein involved in Wnt signaling. Axin2 negatively regulates Wnt signaling and acts as a tumor suppressor protein. The present study evaluated the association between the Axin2 single nucleotide polymorphism (SNP) rs2240308 [guanine (G)/adenine (A)] and the incidence of prostate cancer. In total, 103 patients with prostate cancer and 100 cancer-free control males were included in this case-control study, and were genotyped using the genomic DNA extracted from peripheral blood samples. The results revealed a higher incidence of prostate cancer in the subjects with the homozygous GG genotype and a reduced cancer incidence in the patients with the GA genotype of the rs2240308 SNP (G/A) in the Axin2 gene. The adjusted odds ratio for carriers with the GA genotype was 0.377 (95% CI, 0.206–0.688; P=0.001) and that for the AA genotype was 0.830 (95% CI, 0.309–2.232; P=0.712) compared with the GG genotype. Therefore, the GA genotype was found to exhibit a protective effect that decreased the risk of prostate cancer. To the best of our knowledge, this is the first study to demonstrate the significant association between this SNP (rs2240308, G/A) and the risk of prostate cancer. This association indicates the possibility that the variations in the Axin2 gene in this position may play a significant role in promoting the development of cancer in the prostate. We believe that the Axin2 SNP (rs2240308) could be a useful biomarker for the predisposition and early diagnosis of the disease.
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影响因子：
56.9
作者：
Behrens, J;Jerchow, BA;Birchmeier, W
通讯作者：
Birchmeier, W
影响因子：
4.4
作者：
Mai, M;Qian, CP;Liu, WG
通讯作者：
Liu, WG
DOI：
10.1159/000056942
发表时间：
2001-01-01
期刊：
CYTOGENETICS AND CELL GENETICS
影响因子：
--
作者：
Dong, X;Seelan, RS;Liu, W
通讯作者：
Liu, W
影响因子：
4.3
作者：
Khan, Nighat P.;Pandith, Arshad A.;Mudassar, Syed
通讯作者：
Mudassar, Syed
影响因子：
3.4
作者：
Pinarbasi, Ergun;Gunes, Emine Gulsen;Silig, Yavuz
通讯作者：
Silig, Yavuz