Age-related gene expression changes, and transcriptome wide association study of physical and cognitive aging traits, in the Lothian Birth Cohort 1936.
Age-related gene expression changes, and transcriptome wide association study of physical and cognitive aging traits, in the Lothian Birth Cohort 1936.
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DOI：
10.18632/aging.101333
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发表时间：
2017-12-01
期刊：
影响因子：
--
通讯作者：
Deary IJ
中科院分区：
文献类型：
--
作者：
Harris SE;Riggio V;Evenden L;Gilchrist T;McCafferty S;Murphy L;Wrobel N;Taylor AM;Corley J;Pattie A;Cox SR;Martin-Ruiz C;Prendergast J;Starr JM;Marioni RE;Deary IJ
基因表达受到遗传变异和环境的影响。随着个体年龄的增长，基因表达的变化可能与身体和认知能力的下降有关。我们测量了来自 1936 年洛锡安出生队列成员（平均年龄为 70 岁和 76 岁）的类淋巴母细胞系的全转录组表达水平。 434 名个体的 1,741 个转录本的基因表达水平发生了变化。基因本体富集分析表明免疫系统中涉及的生物过程的富集。对 70 岁时（N=665 至 781）以及死亡率的 11 项认知、健康和生物医学衰老相关特征进行了全转录组关联分析。与非吸烟者相比，先前被鉴定为在吸烟或吸烟相关癌症中差异甲基化或表达的基因（F2RL3、EMILIN1和CDC42BPA）的转录本在吸烟者中过度表达，并且先前与应激反应、自身免疫性疾病和癌症相关的基因（HERPUD1、GAB2、FAM167A和GLS）的转录本表达与端粒长度相关。没有发现表达水平与其他性状或死亡率之间存在关联。
Gene expression is influenced by both genetic variants and the environment. As individuals age, changes in gene expression may be associated with decline in physical and cognitive abilities. We measured transcriptome-wide expression levels in lymphoblastoid cell lines derived from members of the Lothian Birth Cohort 1936 at mean ages 70 and 76 years. Changes in gene expression levels were identified for 1,741 transcripts in 434 individuals. Gene Ontology enrichment analysis indicated an enrichment of biological processes involved in the immune system. Transcriptome-wide association analysis was performed for eleven cognitive, fitness, and biomedical aging-related traits at age 70 years (N=665 to 781) and with mortality. Transcripts for genes (F2RL3, EMILIN1 and CDC42BPA) previously identified as being differentially methylated or expressed in smoking or smoking-related cancers were overexpressed in smokers compared to non-smokers and the expression of transcripts for genes (HERPUD1, GAB2, FAM167A and GLS) previously associated with stress response, autoimmune disease and cancer were associated with telomere length. No associations between expression levels and other traits, or mortality were identified.
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影响因子：
5.8
作者：
Gu, Zuguang;Eils, Roland;Schlesner, Matthias
通讯作者：
Schlesner, Matthias
影响因子：
11
作者：
Davies G;Marioni RE;Liewald DC;Hill WD;Hagenaars SP;Harris SE;Ritchie SJ;Luciano M;Fawns-Ritchie C;Lyall D;Cullen B;Cox SR;Hayward C;Porteous DJ;Evans J;McIntosh AM;Gallacher J;Craddock N;Pell JP;Smith DJ;Gale CR;Deary IJ
通讯作者：
Deary IJ
全基因组甲基化谱揭示了人类衰老速度的定量观点。
影响因子：
16
作者：
Hannum, Gregory;Guinney, Justin;Zhao, Ling;Zhang, Li;Hughes, Guy;Sadda, SriniVas;Klotzle, Brandy;Bibikova, Marina;Fan, Jian-Bing;Gao, Yuan;Deconde, Rob;Chen, Menzies;Rajapakse, Indika;Friend, Stephen;Ideker, Trey;Zhang, Kang
通讯作者：
Zhang, Kang
影响因子：
4.3
作者：
Eden E;Lipson D;Yogev S;Yakhini Z
通讯作者：
Yakhini Z
影响因子：
3.9
作者：
Irizar, Haritz;Goni, Joaquin;Otaegui, David
通讯作者：
Otaegui, David