Application and possible mechanisms of combining LLLT (low level laser therapy), infrared hyperthermia and ionizing radiation in the treatment of cancer
Application and possible mechanisms of combining LLLT (low level laser therapy), infrared hyperthermia and ionizing radiation in the treatment of cancer
复制标题
LLLT（低强度激光疗法）、红外热疗和电离辐射联合治疗癌症的应用及可能机制
DOI：
10.1117/12.2038630
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Frohns
中科院分区：
文献类型：
--
作者：
Abraham;Harlin-Jones;Heselich;Frohns
本研究评估了伴随红外热疗和低水平激光治疗以及电离辐射的益处。目的/目标：局部晚期巨大浅表肿瘤的表现具有临床挑战性。为了提高化疗和IMRT（调强放射治疗）和/或电子束治疗的疗效，我们开发了一种廉价且临床有效的红外热疗方法，该方法将黑体红外辐射与卤素光谱辐射和离散波长红外临床激光LLLT相结合。目标是产生从远红外延伸到近红外和可见光谱的部分的复合光谱，其具有由频率为810 nm和/或830 nm的临床红外激光器产生的离散穿透波长。在放射治疗之前和之后应用来自这些源的复合光谱。我们使用热探头监测表面温度，在某些情况下使用更深的温度，但使用表面探头阵列作为患者治疗中的限制性安全热约束，同时最大限度地增加红外线进入更深的组织层。发热级红外热疗是在最初的几厘米内产生的，而非热红外效应则作用于更深的组织层。这些效应与电离辐射的结合导致许多癌症的肿瘤控制改善。
Benefit of concomitant infrared hyperthermia and low level laser therapy and ionizing radiation is evaluated in this study. The purpose/objectives: presentation with locally advanced bulky superficial tumors is clinically challenging. To enhance the efficacy of chemotherapy and IMRT (intensity-modulated radiation therapy) and/or electron beam therapy we have developed an inexpensive and clinically effective infrared hyperthermia approach that combines black-body infrared radiation with halogen spectrum radiation and discrete wave length infrared clinical lasers LLLT. The goal is to produce a composite spectrum extending from the far infrared to near infrared and portions of the visible spectrum with discrete penetrating wavelengths generated by the clinical infrared lasers with frequencies of 810 nm and/or 830 nm. The composite spectrum from these sources is applied before and after radiation therapy. We monitor the surface and in some cases deeper temperatures with thermal probes, but use an array of surface probes as the limiting safe thermal constraint in patient treatment while at the same time maximizing infrared entry to deeper tissue layers. Fever-grade infrared hyperthermia is produced in the first centimeters while non-thermal infrared effects act at deeper tissue layers. The combination of these effects with ionizing radiation leads to improved tumor control in many cancers.
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影响因子：
11.2
作者：
Laszlo, Andrei;Fleischer, Ilona
通讯作者：
Fleischer, Ilona
影响因子：
11.2
作者：
Hunt, Clayton R.;Pandita, Raj K.;Pandita, Tej K.
通讯作者：
Pandita, Tej K.
影响因子：
3.1
作者：
Hua, Yonghong;Ma, Shenglin;Piao, Yongfeng
通讯作者：
Piao, Yongfeng
影响因子：
11.2
作者：
Takahashi, A;Matsumoto, H;Ohnishi, T
通讯作者：
Ohnishi, T