Five gene variants in nonagenarians, centenarians and average individuals.
Five gene variants in nonagenarians, centenarians and average individuals.
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在非亲切者，百岁老人和普通人中的五个基因变体。
DOI：
10.5114/aoms.2017.68942
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发表时间：
2017-08
期刊：
影响因子：
--
通讯作者：
Kolovou G
中科院分区：
文献类型：
--
作者：
Kolovou V;Bilianou H;Giannakopoulou V;Kalogeropoulos P;Mihas C;Kouris M;Cokkinos DV;Boutsikou M;Hoursalas I;Mavrogeni S;Katsiki N;Kolovou G
遗传因素导致了人类寿命的变化，人们认为85岁以后寿命的变化会更深刻。本研究的目的是评估5个基因多态性在非老年、百岁老人和普通个体之间的频率。对405名个体的端粒酶逆转录酶(TERT；rs2736098)、胰岛素样生长因子-1结合蛋白-3(IGFBP3；A-202C，rs2857744)、叉头盒O3A(FOXO3a；rs13217795和rs2764264)因子和脂联素(ADIPOQ；rs2241766)的单核苷酸多态性(SNPs)进行了研究。研究组的女性比例显著高于对照组(64.5%比49.7%，p=0.004)。基因型别和等位基因频率在不同性别的人群中没有差异。然而，在男性中，研究组FOXO3a；rs2764264的TT基因型频率高于对照组(45.6%vs.28.0%，P=0.05)。总体而言，研究组FOXO3a；rs2764264的C等位基因频率显著低于对照组(分别为3.9%和9.5%，p=0.023)。此外，在研究组中，在FOXO3a、rs13217795和rs2764264中，非老年组(n=239)T等位基因的频率显著高于百岁组(n=17)(分别为64.4vs.44.1%，p=0.018和69.7vs.50.0%，p=0.017)。根据生存状况，两种研究的FOXO3a基因多态的患病率存在差异。与对照组相比，研究组有一半的C等位基因，百岁老人与非老年人相比，两个FOXO3a基因多态的T等位基因的频率较低。TERT、IGFBP3和ADIPOQ基因多态性在组间差异无统计学意义。看起来，一些基因多态可能对延长我们的寿命有重要意义。然而，还需要在更多的研究人群中进行确认。
Genetic factors contribute to the variation of human life span which is believed to be more profound after 85 years of age. The aim of the present study was to evaluate the frequency of 5 gene polymorphisms between nonagenarians, centenarians and average individuals. Single nucleotide polymorphisms (SNPs) of telomerase reverse transcriptase (TERT; rs2736098), insulin-like growth factor-1 binding protein-3 (IGFBP3; A-202C, rs2857744), fork-head box O3A (FOXO3A; rs13217795 and rs2764264) factor and adiponectin (ADIPOQ; rs2241766) were evaluated in 405 individuals: n = 256 nonagenarians and centenarians (study group) and n = 149 average lifespan individuals (control group aged 18 – < 80 years). The frequency of women was significantly higher in the study group than the control group (64.5 vs. 49.7%, p = 0.004). Genotypic and allele frequencies did not differ between groups according to gender. However, in men, the frequency of TT genotype of FOXO3A; rs2764264 was higher in the study group than the control group (45.6 vs. 28.0%, p = 0.05). Overall, the frequency of the C allele of FOXO3A; rs2764264 was significantly lower in the study group than the control group (3.9 vs. 9.5%, respectively, p = 0.023). Furthermore, in the study group, the T allele was significantly more frequent in the nonagenarians (n = 239) than the centenarians (n = 17) in both FOXO3A; rs13217795 and rs2764264 (64.4 vs. 44.1%, p = 0.018 and 69.7 vs. 50.0%, p = 0.017, respectively). According to survival status, there is differentiation in the prevalence of both studied FOXO3A gene polymorphisms. The study group had half of the C alleles compared with the control group and centenarians less frequently had the T allele of both FOXO3A gene polymorphisms compared with nonagenarians. No difference was found between groups according to TERT, IGFBP3 and ADIPOQ gene polymorphisms. It seems that some polymorphisms may be significant in prolonging our lifespan. Nevertheless, confirmation in additional study populations is needed.
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DOI：
10.18632/aging.100703
发表时间：
2014-11
期刊：
Aging
影响因子：
--
作者：
He YH;Lu X;Yang LQ;Xu LY;Kong QP
通讯作者：
Kong QP
影响因子：
--
作者：
Bressler J;Franceschini N;Demerath EW;Mosley TH;Folsom AR;Boerwinkle E
通讯作者：
Boerwinkle E
DOI：
10.1093/gerona/63.5.447
发表时间：
2008-05-01
影响因子：
5.1
作者：
Atzmon, Gil;Pollin, Toni I.;Barzilai, Nir
通讯作者：
Barzilai, Nir
影响因子：
64.8
作者：
BUCKBINDER, L;TALBOTT, R;KLEY, N
通讯作者：
KLEY, N
影响因子：
4.4
作者：
Hinman, Rochelle M.;Nichols, Whitney A.;Satterthwaite, Anne B.
通讯作者：
Satterthwaite, Anne B.