Elevated PCNA+ tumor-associated macrophages in breast cancer are associated with early recurrence and non-Caucasian ethnicity
Elevated PCNA+ tumor-associated macrophages in breast cancer are associated with early recurrence and non-Caucasian ethnicity
复制标题
乳腺癌中 PCNA 肿瘤相关巨噬细胞升高与早期复发和非白种人种相关
DOI：
--
复制
发表时间：
2011
影响因子：
3.8
通讯作者：
L. Esserman
中科院分区：
文献类型：
--
作者：
R. Mukhtar;A. Moore;O. Nseyo;F. Baehner;A. Au;D. Moore;P. Twomey;M. Campbell;L. Esserman
African American and Hispanic women develop more triple negative breast cancer at younger ages than Caucasian women. The frequently observed association between race and socioeconomic status (SES) has confounded our understanding of the outcomes disparities seen in these groups. Given the association between inflammatory cells and high-grade, triple negative tumors, we sought to investigate whether differences in the presence of these cells varies by race. We evaluated breast tumor specimens for the presence PCNA+ tumor-associated macrophages (TAMs) in consecutive cases from a county hospital serving primarily un- or under-insured patients. All patients in this cohort had elevated PCNA + TAM levels. Higher PCNA + TAM counts were associated with hormone receptor (HR) negative tumors and non-Caucasian ethnicity. Hispanic women specifically had significantly higher PCNA + TAM counts than Caucasian patients and shorter disease-free survival. These findings implicate immune function in the development of aggressive breast cancer and suggest a possible link between SES and the inflammatory response.
登录
查看更多内容
影响因子：
11.2
作者：
Eubank TD;Roberts RD;Khan M;Curry JM;Nuovo GJ;Kuppusamy P;Marsh CB
通讯作者：
Marsh CB
DOI：
10.1056/nejmoa0905680
发表时间：
2010-03-11
期刊：
The New England journal of medicine
影响因子：
--
作者：
Steidl C;Lee T;Shah SP;Farinha P;Han G;Nayar T;Delaney A;Jones SJ;Iqbal J;Weisenburger DD;Bast MA;Rosenwald A;Muller-Hermelink HK;Rimsza LM;Campo E;Delabie J;Braziel RM;Cook JR;Tubbs RR;Jaffe ES;Lenz G;Connors JM;Staudt LM;Chan WC;Gascoyne RD
通讯作者：
Gascoyne RD
影响因子：
4.8
作者：
Lee, YC;Tang, YC;Tsou, AP
通讯作者：
Tsou, AP
影响因子：
120.7
作者：
Carey, Lisa A.;Perou, Charles M.;Millikan, Robert C.
通讯作者：
Millikan, Robert C.
影响因子：
10.3
作者：
Albain, Kathy S.;Unger, Joseph M.;Hershman, Dawn L.
通讯作者：
Hershman, Dawn L.