Multifunctional and stimuli-sensitive pharmaceutical nanocarriers.
Multifunctional and stimuli-sensitive pharmaceutical nanocarriers.
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DOI：
10.1016/j.ejpb.2008.09.026
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发表时间：
2009-03
期刊：
影响因子：
--
通讯作者：
Torchilin V
中科院分区：
文献类型：
--
作者：
Torchilin V
目前使用的药物纳米载体，如脂质体、胶束和聚合物纳米颗粒，显示出各种各样的有用特性，例如在体内的寿命；对某些疾病部位的特异性靶向；细胞内渗透增强；对比特性允许体内载体的直接可视化；刺激敏感性等。其中一些药物载体已经进入临床，而另一些仍处于临床前开发阶段。在某些情况下，药物纳米载体结合了列出的几种性质。长循环的免疫脂质体能够在血液中长时间停留并识别特定的靶标，这就是其中的一个例子。多功能药物纳米载体的工程将多种有用的特性结合在一个粒子中，可以显着提高许多治疗和诊断方案的功效。本文考虑了多功能纳米载体的现状和未来可能的发展方向，重点关注了多功能纳米载体的寿命、靶向性、细胞内穿透性、对比度负载和刺激敏感性等特性的结合。
Currently used pharmaceutical nanocarriers, such as liposomes, micelles, and polymeric nanoparticles, demonstrate a broad variety of useful properties, such as longevity in the body; specific targeting to certain disease sites; enhanced intracellular penetration; contrast properties allowing for direct carrier visualization in vivo; stimili-sensitivity, and others. Some of those pharmaceutical carriers have already made their way into clinic, while others are still under preclinical development. In certain cases, the pharmaceutical nanocarriers combine several of the listed properties. Long-circulating immunoliposomes capable of prolonged residence in the blood and specific target recognition represent one of examples of this kind. The engineering of multifunctional pharmaceutical nanocarriers combining several useful properties in one particle can significantly enhance the efficacy of many therapeutic and diagnostic protocols. This paper considers the current status and possible future directions in the emerging area of multifunctional nanocarriers with primary attention on the combination of such properties as longevity, targetability, intracellular penetration, contrast loading, and stimuli sensitivity.
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影响因子：
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作者：
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