A three-generation study on the association of tobacco smoking with asthma.
A three-generation study on the association of tobacco smoking with asthma.
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DOI：
10.1093/ije/dyy031
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发表时间：
2018-08-01
影响因子：
7.7
通讯作者：
Ageing Lungs in European Cohorts (ALEC) Study
中科院分区：
文献类型：
--
作者：
Accordini S;Calciano L;Johannessen A;Portas L;Benediktsdóttir B;Bertelsen RJ;Bråbäck L;Carsin AE;Dharmage SC;Dratva J;Forsberg B;Gomez Real F;Heinrich J;Holloway JW;Holm M;Janson C;Jögi R;Leynaert B;Malinovschi A;Marcon A;Martínez-Moratalla Rovira J;Raherison C;Sánchez-Ramos JL;Schlünssen V;Bono R;Corsico AG;Demoly P;Dorado Arenas S;Nowak D;Pin I;Weyler J;Jarvis D;Svanes C;Ageing Lungs in European Cohorts (ALEC) Study
母亲在怀孕期间吸烟会增加其后代患哮喘的风险。有一些证据表明祖母吸烟可能有类似的影响，而父亲在青春期吸烟可能通过精子前体细胞中可传播的表观遗传变化影响后代的健康。我们评估了吸烟与哮喘的三代关联。在2010年至2013年期间，在欧洲共同体呼吸健康调查III临床访谈中，来自26个中心的2233名母亲和1964名父亲报告了他们的后代（年龄≤51岁）是否患有哮喘以及是否与鼻过敏共存。母亲和父亲还提供了他们父母（祖父母）和他们自己的哮喘、教育和吸烟史的信息。多中心的三代框架内的多层次中介模型分别适合在母亲（4666后代）和父亲（4192后代）线。父亲在15岁以前吸烟[相对危险比（RRR）= 1.43，95%可信区间（CI）：1.01-2.01]和母亲在怀孕期间吸烟（RRR = 1.27，95% CI：1.01-1.59）与其后代无鼻过敏的哮喘相关。祖母在怀孕期间吸烟与其女儿的哮喘相关[比值比（OR）= 1.55，95%CI：1.17-2.06]，与其母系孙辈的哮喘伴鼻过敏相关（RRR = 1.25，95%CI：1.02-1.55）。父亲在青春期早期吸烟，祖母和母亲在怀孕期间吸烟可能独立地增加后代的哮喘风险。因此，哮喘的危险因素应该在父母双方和怀孕前寻找。欧盟（Horizon 2020，GA-633212）。
Mothers’ smoking during pregnancy increases asthma risk in their offspring. There is some evidence that grandmothers’ smoking may have a similar effect, and biological plausibility that fathers’ smoking during adolescence may influence offspring’s health through transmittable epigenetic changes in sperm precursor cells. We evaluated the three-generation associations of tobacco smoking with asthma. Between 2010 and 2013, at the European Community Respiratory Health Survey III clinical interview, 2233 mothers and 1964 fathers from 26 centres reported whether their offspring (aged ≤51 years) had ever had asthma and whether it had coexisted with nasal allergies or not. Mothers and fathers also provided information on their parents’ (grandparents) and their own asthma, education and smoking history. Multilevel mediation models within a multicentre three-generation framework were fitted separately within the maternal (4666 offspring) and paternal (4192 offspring) lines. Fathers’ smoking before they were 15 [relative risk ratio (RRR) = 1.43, 95% confidence interval (CI): 1.01–2.01] and mothers’ smoking during pregnancy (RRR = 1.27, 95% CI: 1.01–1.59) were associated with asthma without nasal allergies in their offspring. Grandmothers’ smoking during pregnancy was associated with asthma in their daughters [odds ratio (OR) = 1.55, 95% CI: 1.17–2.06] and with asthma with nasal allergies in their grandchildren within the maternal line (RRR = 1.25, 95% CI: 1.02–1.55). Fathers’ smoking during early adolescence and grandmothers’ and mothers’ smoking during pregnancy may independently increase asthma risk in offspring. Thus, risk factors for asthma should be sought in both parents and before conception. European Union (Horizon 2020, GA-633212).
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DOI：
10.1016/j.jaci.2016.12.002
发表时间：
2017-02
期刊：
The Journal of allergy and clinical immunology
影响因子：
--
作者：
Arshad SH;Karmaus W;Zhang H;Holloway JW
通讯作者：
Holloway JW
影响因子：
3
作者：
Lutz SM;Thwing A;Schmiege S;Kroehl M;Baker CD;Starling AP;Hokanson JE;Ghosh D
通讯作者：
Ghosh D
DOI：
10.1164/rccm.200610-1507oc
发表时间：
2007-11-01
影响因子：
24.7
作者：
Guilbert, Theresa W.;Stern, Debra A.;Wright, Anne L.
通讯作者：
Wright, Anne L.
影响因子：
9.6
作者：
Li, YF;Langholz, B;Gilliland, FD
通讯作者：
Gilliland, FD
影响因子：
24.3
作者：
Jarvis, D
通讯作者：
Jarvis, D