Mechanisms of carbon nanotube-induced pulmonary fibrosis: a physicochemical characteristic perspective.
Mechanisms of carbon nanotube-induced pulmonary fibrosis: a physicochemical characteristic perspective.
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DOI：
10.1002/wnan.1498
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发表时间：
2018-05
期刊：
影响因子：
--
通讯作者：
Bonner JC
中科院分区：
文献类型：
--
作者：
Duke KS;Bonner JC
碳纳米管（CNT）是具有许多有益应用的工程纳米材料（ENM）。然而，由于职业接触或消费者接触，它们可能对人类健康构成风险。啮齿动物模型表明，通过吸入，滴注或抽吸暴露于CNT导致肺纤维化。纤维化反应的严重程度取决于纳米材料的各种理化性质，如残留金属催化剂含量、刚性、长度、聚集状态或表面电荷。碳纳米管也越来越多地在合成后用有机或无机试剂官能化以改性或增强表面性质。CNT诱导的纤维化的机制涉及氧化应激、巨噬细胞的先天免疫应答、细胞因子和生长因子的产生、上皮细胞损伤和死亡、肺肌成纤维细胞群体的扩增以及随后的细胞外基质积累。全面了解物理化学性质如何影响各种类型碳纳米管的纤维化潜力，应结合遗传变异性以及编码分泌细胞因子、酶或细胞内细胞信号分子的特定基因的功能获得或丧失来考虑。在这里，我们涵盖了目前状态的文献CNT暴露的肺纤维化的啮齿动物模型的机制，重点是物理化学特征的机制，导致肺纤维化的主要驱动程序。肺暴露于碳纳米管可导致与肺中细胞的直接相互作用，并导致肌成纤维细胞群增加，从而增强纤维形成，其严重程度由纳米管的物理化学特征和遗传易感性决定。
Carbon nanotubes (CNTs) are engineered nanomaterials (ENMs) with numerous beneficial applications. However, they could pose a risk to human health from occupational or consumer exposures. Rodent models demonstrate that exposure to CNTs via inhalation, instillation, or aspiration results in pulmonary fibrosis. The severity of the fibrogenic response is determined by various physicochemical properties of the nanomaterial such as residual metal catalyst content, rigidity, length, aggregation status, or surface charge. CNTs are also increasingly functionalized post-synthesis with organic or inorganic agents to modify or enhance surface properties. The mechanisms of CNT-induced fibrosis involve oxidative stress, innate immune responses of macrophages, cytokine and growth factor production, epithelial cell injury and death, expansion of the pulmonary myofibroblast population, and consequent extracellular matrix accumulation. A comprehensive understanding of how physicochemical properties affect the fibrogenic potential of various types of CNTs should be considered in combination with genetic variability and gain or loss of function of specific genes encoding secreted cytokines, enzymes, or intracellular cell signaling molecules. Here we cover the current state of the literature on mechanisms of CNT-exposed pulmonary fibrosis in rodent models with a focus on physicochemical characteristics as principal drivers of the mechanisms leading to pulmonary fibrosis. Pulmonary exposure to carbon nanotubes can result in direct interaction with cells in the lung and result in an increased myofibroblast population thereby enhancing fibrogenesis, the severity of which is determined by physicochemical characteristics of the nanotubes and genetic susceptibility.
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DOI：
10.1016/j.nano.2015.11.011
发表时间：
2016-02
期刊：
Nanomedicine : nanotechnology, biology, and medicine
影响因子：
--
作者：
Bhattacharya K;Mukherjee SP;Gallud A;Burkert SC;Bistarelli S;Bellucci S;Bottini M;Star A;Fadeel B
通讯作者：
Fadeel B
影响因子：
10.4
作者：
Bonner JC;Silva RM;Taylor AJ;Brown JM;Hilderbrand SC;Castranova V;Porter D;Elder A;Oberdörster G;Harkema JR;Bramble LA;Kavanagh TJ;Botta D;Nel A;Pinkerton KE
通讯作者：
Pinkerton KE
影响因子：
3.7
作者：
Aoki, Yasuhiro;Maeno, Toshitaka;Kurabayashi, Masahiko
通讯作者：
Kurabayashi, Masahiko
影响因子：
11.4
作者：
Cartwright, Megan M.;Schmuck, Stefanie C.;Corredor, Charlie;Wang, Bingbing;Scoville, David K.;Chisholm, Claire R.;Wilkerson, Hui-Wen;Afsharinejad, Zahra;Bammler, Theodor K.;Posner, Jonathan D.;Shutthanandan, Vaithiyalingam;Baer, Donald R.;Mitra, Somenath;Altemeier, William A.;Kavanagh, Terrance J.
通讯作者：
Kavanagh, Terrance J.
影响因子：
3.5
作者：
Chen, Tian;Nie, Haiyu;Jia, Guang
通讯作者：
Jia, Guang