A shape memory foam composite with enhanced fluid uptake and bactericidal properties as a hemostatic agent.
A shape memory foam composite with enhanced fluid uptake and bactericidal properties as a hemostatic agent.
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DOI：
10.1016/j.actbio.2016.10.008
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发表时间：
2017-01-01
影响因子：
9.7
通讯作者：
Cosgriff-Hernandez E
中科院分区：
文献类型：
--
作者：
Landsman TL;Touchet T;Hasan SM;Smith C;Russell B;Rivera J;Maitland DJ;Cosgriff-Hernandez E
不受控制的出血占全球创伤死亡的30%以上。目前的止血装置主要关注止血时间，但预防细菌感染对于提高生存率也至关重要。在这项研究中，我们试图通过将形状记忆聚合物（SMP）泡沫的大体积填充能力和快速凝固与水凝胶的溶胀能力相结合来改善目前用于出血控制的器械。此外，选择易于与元素碘络合以赋予装置杀菌性质的水凝胶组合物。这项工作的重点是验证每种材料（SMP泡沫和水凝胶）在复合器械中组合时的优势。碘掺杂的水凝胶表现出80%的细菌活力减少时，培养高生物负荷的金黄色葡萄球菌。SMP泡沫的水凝胶涂层使流体吸收比未涂覆的SMP泡沫增加19倍。复合材料装置在浸没在37°C水中15分钟后保持泡沫的形状记忆行为，具有超过15倍的体积膨胀。最后，测试复合材料的扩张力，以评估器械扩张期间伤口内的潜在组织损伤。扩张力不超过0.6 N，即使扩张后的器械直径显著大于目标伤口部位，器械扩张期间也不太可能造成组织损伤。总之，形状记忆泡沫复合材料的增强的流体吸收和杀菌性质表明其作为止血剂治疗不可压缩伤口的强大潜力。
Uncontrolled hemorrhage accounts for more than 30% of trauma deaths worldwide. Current hemostatic devices focus primarily on time to hemostasis, but prevention of bacterial infection is also critical for improving survival rates. In this study, we sought to improve on current devices used for hemorrhage control by combining the large volume-filling capabilities and rapid clotting of shape memory polymer (SMP) foams with the swelling capacity of hydrogels. In addition, a hydrogel composition was selected that readily complexes with elemental iodine to impart bactericidal properties to the device. The focus of this work was to verify that the advantages of each respective material (SMP foam and hydrogel) are retained when combined in a composite device. The iodine-doped hydrogel demonstrated an 80% reduction in bacteria viability when cultured with a high bioburden of Staphylococcus aureus. Hydrogel coating of the SMP foam increased fluid uptake by 19X over the uncoated SMP foam. The composite device retained the shape memory behavior of the foam with more than 15X volume expansion after being submerged in 37°C water for 15 minutes. Finally, the expansion force of the composite was tested to assess potential tissue damage within the wound during device expansion. Expansion forces did not exceed 0.6 N, making tissue damage during device expansion unlikely, even when the expanded device diameter is substantially larger than the target wound site. Overall, the enhanced fluid uptake and bactericidal properties of the shape memory foam composite indicate its strong potential as a hemostatic agent to treat non-compressible wounds.
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影响因子：
2.4
作者：
Kim, Dong Bin;Choi, Hyuk;Sun, Kyung
通讯作者：
Sun, Kyung
DOI：
10.1007/s10840-011-9552-6
发表时间：
2011-08-01
影响因子：
1.8
作者：
Sairaku, Akinori;Nakano, Yukiko;Kihara, Yasuki
通讯作者：
Kihara, Yasuki
DOI：
10.1097/01.ta.0000199392.91772.44
发表时间：
2006-03-01
影响因子：
--
作者：
Wedmore, I;McManus, JG;Holcomb, JB
通讯作者：
Holcomb, JB
DOI：
10.1016/j.jmbbm.2014.07.037
发表时间：
2014-12
影响因子：
3.9
作者：
Rodriguez, Jennifer N.;Miller, Matthew W.;Boyle, Anthony;Horn, John;Yang, Cheng-Kang;Wilson, Thomas S.;Ortega, Jason M.;Small, Ward;Nash, Landon;Skoog, Hunter;Maitland, Duncan J.
通讯作者：
Maitland, Duncan J.
影响因子：
2.2
作者：
ROBSON, MC;DUKE, WF;KRIZEK, TJ
通讯作者：
KRIZEK, TJ